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Verfasst von:Klotz, Daniel Martin [VerfasserIn]   i
 Kuhlmann, Jan Dominik [VerfasserIn]   i
 Link, Theresa [VerfasserIn]   i
 Goeckenjan, Maren [VerfasserIn]   i
 Hofbauer, Lorenz C. [VerfasserIn]   i
 Göbel, Andy [VerfasserIn]   i
 Rachner, Tilman D. [VerfasserIn]   i
 Wimberger, Pauline [VerfasserIn]   i
Titel:Clinical impact of soluble Neuropilin-1 in ovarian cancer patients and its association with its circulating ligands of the HGF/c-MET axis
Verf.angabe:Daniel Martin Klotz, Jan Dominik Kuhlmann, Theresa Link, Maren Goeckenjan, Lorenz C. Hofbauer, Andy Göbel, Tilman D. Rachner and Pauline Wimberger
E-Jahr:2022
Jahr:21 October 2022
Umfang:10 S.
Fussnoten:Gesehen am 11.01.2023
Titel Quelle:Enthalten in: Frontiers in oncology
Ort Quelle:Lausanne : Frontiers Media, 2011
Jahr Quelle:2022
Band/Heft Quelle:12(2022) vom: Okt., Artikel-ID 974885, Seite 1-10
ISSN Quelle:2234-943X
Abstract:BackgroundNeuropilin (NRP) is a transmembrane protein, which has been shown to be a pro-angiogenic mediator and implicated as a potential driver of cancer progression. NRP-1 up-regulation in ovarian cancer tissue predicts poor prognosis. However, the clinical relevance of the soluble form of NRP-1 (sNRP-1) as a circulating biomarker in ovarian cancer patients is unknown.Methods/patients cohortsNRP-1 levels were quantified in a cohort of 88 clinically documented ovarian cancer patients by a commercially available sNRP-1 enzyme-linked immunosorbent assay (ELISA) kit (Biomedica, Vienna, Austria). Patients (81.8% with FIGOIII/IV) received primary cytoreductive surgery with the aim of macroscopic complete resection (achieved in 55.7% of patients) and the recommendation of adjuvant chemotherapy in line with national guidelines.ResultsHigher levels of sNRP-1 reflected more advanced disease (FIGO III/IV) and indicated a trend towards suboptimal surgical outcome, i.e. any residual tumor. sNRP-1 was neither related to the patients’ age nor the BRCA1/2 mutational status. Patients with higher sNRP-1 levels at primary diagnosis had a significantly reduced progression-free survival (PFS) (HR = 0.541, 95%CI: 0.304 - 0.963; p = 0.037) and overall survival (OS) (HR = 0.459, 95%CI: 0.225 - 0.936; p = 0.032). Principal component analysis showed that sNRP-1 levels were unrelated to the circulating hepatocyte growth factor (HGF) and the soluble ectodomain of its receptor the tyrosine kinase mesenchymal-epithelial transition (c-MET), suggesting that there is no proportional serological concentration gradient of soluble components of the NRP-1/HGF/c-MET signaling axis.ConclusionsIn line with the previously shown tissue-based prognostic role, we demonstrated for the first time that sNRP-1 can also act as a readily accessible, prognostic biomarker in the circulation of patients with ovarian cancer at primary diagnosis. Given its known role in angiogenesis and conferring resistance to the poly ADP-ribose polymerase (PARP) inhibitor olaparib in vitro, our results encourage more detailed investigation into sNRP-1 as a potential predictive biomarker for bevacizumab and/or PARP-inhibitor treatment.
DOI:doi:10.3389/fonc.2022.974885
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3389/fonc.2022.974885
 Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2022.974885
 DOI: https://doi.org/10.3389/fonc.2022.974885
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1830824430
Verknüpfungen:→ Zeitschrift

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