Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Porubský, Štefan [VerfasserIn]   i
 Wang, Shijun [VerfasserIn]   i
 Kiss, Eva [VerfasserIn]   i
 Dehmel, Stefan [VerfasserIn]   i
 Bonrouhi, Mahnaz [VerfasserIn]   i
 Dorn, Tatjana [VerfasserIn]   i
 Luckow, Bruno [VerfasserIn]   i
 Brakebusch, Cord [VerfasserIn]   i
 Gröne, Hermann-Josef [VerfasserIn]   i
Titel:Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection
Verf.angabe:Stefan Porubsky, Shijun Wang, Eva Kiss, Stefan Dehmel, Mahnaz Bonrouhi, Tatjana Dorn, Bruno Luckow, Cord Brakebusch and Hermann-Josef Gröne
Jahr:2011
Umfang:13 S.
Fussnoten:First published: 13 October 2010 ; Gesehen am 12.01.2023
Titel Quelle:Enthalten in: European journal of immunology
Ort Quelle:Weinheim : Wiley-VCH, 1971
Jahr Quelle:2011
Band/Heft Quelle:41(2011), 1, Seite 76-88
ISSN Quelle:1521-4141
Abstract:Rhoh is a hematopoietic system-specific GTPase. Rhoh-deficient T cells have been shown to have a defect in TCR signaling manifested during their thymic development. Our aims were to investigate the phenotype of peripheral Rhoh-deficient T cells and to explore in vivo the potential benefit of Rhoh deficiency in a clinically relevant situation, in which T-cell inhibition is desirable. In murine allogenic kidney transplantation, Rhoh deficiency caused a significant 75% reduction of acute and chronic transplant rejection accompanied by 75% lower alloantigen-specific antibody levels and significantly better graft function. This effect was independent of the lower T-cell numbers in Rhoh-deficient recipients, because injection of equal numbers of Rhoh-deficient or control T cells into kidney transplanted mice with SCID led again to a significant 60% reduction of rejection. Mixed lymphocyte reaction revealed that the weaker alloreactivity was associated with a 85% lower cytotoxicity and a 50-80% lower cytokine release in Rhoh-deficient T cells without an influence on the secretion itself. Antigen uptake and presentation in DC were unaffected by Rhoh deficiency. These findings stress the importance of Rhoh for the function of peripheral T cells.
DOI:doi:10.1002/eji.201040420
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/eji.201040420
 DOI: https://doi.org/10.1002/eji.201040420
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Acute Disease
 Animals
 Antibodies
 Antigen Presentation
 Chronic Disease
 Cytokines
 Dendritic Cells
 Graft Rejection
 Isoantigens
 Kidney Transplantation
 Lymphocyte Culture Test, Mixed
 Male
 Mice
 Mice, Inbred BALB C
 Mice, Mutant Strains
 Mice, SCID
 rho GTP-Binding Proteins
 T-Lymphocytes
 Transcription Factors
K10plus-PPN:1830990225
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69005636   QR-Code
zum Seitenanfang