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| Verfasst von: | Böttinger, Boris William [VerfasserIn]  |
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| | Baumeister, Sarah [VerfasserIn] |
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| | Millenet, Sabina [VerfasserIn] |
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| | Barker, Gareth J. [VerfasserIn] |
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| | Bokde, Arun L. W. [VerfasserIn] |
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| | Büchel, Christian [VerfasserIn] |
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| | Quinlan, Erin Burke [VerfasserIn] |
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| | Desrivières, Sylvane [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Grigis, Antoine [VerfasserIn] |
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| | Garavan, Hugh [VerfasserIn] |
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| | Gowland, Penny [VerfasserIn] |
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| | Heinz, Andreas [VerfasserIn] |
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| | Ittermann, Bernd [VerfasserIn] |
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| | Martinot, Jean-Luc [VerfasserIn] |
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| | Martinot, Marie-Laure Paillère [VerfasserIn] |
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| | Artiges, Eric [VerfasserIn] |
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| | Orfanos, Dimitri Papadopoulos [VerfasserIn] |
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| | Paus, Tomáš [VerfasserIn] |
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| | Poustka, Luise [VerfasserIn] |
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| | Fröhner, Juliane H. [VerfasserIn] |
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| | Smolka, Michael N. [VerfasserIn] |
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| | Walter, Henrik [VerfasserIn] |
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| | Whelan, Robert [VerfasserIn] |
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| | Schumann, Gunter [VerfasserIn] |
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| | Banaschewski, Tobias [VerfasserIn] |
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| | Brandeis, Daniel [VerfasserIn] |
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| | Nees, Frauke [VerfasserIn] |
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| Titel: | Orbitofrontal control of conduct problems? |
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| Titelzusatz: | evidence from healthy adolescents processing negative facial affect |
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| Verf.angabe: | Boris William Böttinger, Sarah Baumeister, Sabina Millenet, Gareth J. Barker, Arun L. W. Bokde, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Tobias Banaschewski, Daniel Brandeis, Frauke Nees, IMAGEN Consortium |
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| Jahr: | 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Published online: 16 April 2021 ; Gesehen am 16.01.2023 |
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| Titel Quelle: | Enthalten in: European child & adolescent psychiatry |
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| Ort Quelle: | Darmstadt : Steinkopff, 1992 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 31(2022), Seite 1307-1316 |
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| ISSN Quelle: | 1435-165X |
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| Abstract: | Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents. |
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| DOI: | doi:10.1007/s00787-021-01770-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00787-021-01770-1 |
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| | DOI: https://doi.org/10.1007/s00787-021-01770-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adolescence |
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| | Affective processing |
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| | Conduct problems |
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| | FMRI |
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| | Orbitofrontal cortex |
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| | Subclinical |
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| K10plus-PPN: | 1831118475 |
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| Verknüpfungen: | → Zeitschrift |
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Orbitofrontal control of conduct problems? / Böttinger, Boris William [VerfasserIn]; 2022 (Online-Ressource)
