Exploitation of cellular pathways by dengue virus

• Verfasst von: Fischl, Wolfgang [VerfasserIn]
• Verfasst von: Bartenschlager, Ralf [VerfasserIn]
• Titel: Exploitation of cellular pathways by dengue virus
• Verf.angabe: Wolfgang Fischl and Ralf Bartenschlager
• Jahr: 2011
• Umfang: 6 S.
• Fussnoten: Teil der Sonderausgabe: Host-microbe interactions: fungi/parasites/viruses ; Online verfügbar ab 27. Juli 2011 ; Gesehen am 16.01.2023
• Titel Quelle: Enthalten in: Current opinion in microbiology
• Ort Quelle: London : Current Biology Ltd., 1998
• Jahr Quelle: 2011
• Band/Heft Quelle: 14(2011), 4, special issue vom: Aug., Seite 470-475
• ISSN Quelle: 1879-0364
• DOI: doi:10.1016/j.mib.2011.07.012
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1831151448

Abstract

Dengue virus (DENV) is the causative agent of the most prevalent arthropod-borne viral disease, thus representing a significant global health burden. Because of its limited coding capacity, DENV exploits components and pathways of the host cell to assure productive replication. In the past few years, important insights into this intimate interaction between DENV and the host cell have been gained. These include the identification of the ER-associated degradation pathway, autophagy, the unfolded protein response or lipid droplets that all play a crucial role for efficient DENV replication. In addition, strategies used by the virus to combat innate antiviral responses have been unraveled. Improving our understanding of the DENV-host cell relation will facilitate our attempts to develop efficient antiviral strategies.