| |  Online-Ressource |
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| Verfasst von: | Kann, Oliver [VerfasserIn]  |
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| | Almouhanna, Fadi [VerfasserIn] |
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| | Chausse de Freitas, Bruno [VerfasserIn] |
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| Titel: | Interferon γ |
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| Titelzusatz: | a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration |
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| Verf.angabe: | Oliver Kann, Fadi Almouhanna, and Bruno Chausse |
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| E-Jahr: | 2022 |
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| Jahr: | 22 October 2022 |
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| Umfang: | 15 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Version vom 15. November 2022 ; Gesehen am 17.01.2023 |
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| Titel Quelle: | Enthalten in: Trends in neurosciences |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1978 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 45(2022), 12 vom: Dez., Seite 913-927 |
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| ISSN Quelle: | 1878-108X |
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| Abstract: | Traditionally, lymphocytic interferon γ (IFN-γ) was considered to be a simple 'booster' of proinflammatory responses by microglia (brain-resident macrophages) during bacterial or viral infection. Recent slice culture (in situ) and in vivo studies suggest, however, that IFN-γ has a unique role in microglial activation. Priming by IFN-γ results in proliferation (microgliosis), enhanced synapse elimination, and moderate nitric oxide release sufficient to impair synaptic transmission, gamma rhythm activity, and cognitive functions. Moreover, IFN-γ is pivotal for driving Toll-like receptor (TLR)-activated microglia into neurotoxic phenotypes that induce energetic and oxidative stress, severe network dysfunction, and neuronal death. Pharmacological targeting of activated microglia could be beneficial during elevated IFN-γ levels, blood-brain barrier leakage, and parenchymal T lymphocyte infiltration associated with, for instance, encephalitis, multiple sclerosis, and Alzheimer's disease. |
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| DOI: | doi:10.1016/j.tins.2022.10.007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.tins.2022.10.007 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0166223622002089 |
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| | DOI: https://doi.org/10.1016/j.tins.2022.10.007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | immunometabolism |
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| | inflammation |
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| | microglial priming |
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| | neuronal oscillations |
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| | neurotransmission |
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| | Toll-like receptor |
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| K10plus-PPN: | 1831247038 |
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| Verknüpfungen: | → Zeitschrift |
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