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| Verfasst von: | Gonzalez, Patricia [VerfasserIn]  |
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| | Prado-Rodriguez, Roberto [VerfasserIn] |
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| | Gabor, Attila [VerfasserIn] |
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| | Sáez Rodríguez, Julio [VerfasserIn] |
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| | Banga, Julio R. [VerfasserIn] |
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| | Doallo, Ramón [VerfasserIn] |
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| Titel: | Parallel ant colony optimization for the training of cell signaling networks |
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| Verf.angabe: | Patricia González, Roberto Prado-Rodriguez, Attila Gábor, Julio Saez-Rodriguez, Julio R. Banga, Ramón Doallo |
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| E-Jahr: | 2022 |
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| Jahr: | 20 July 2022 |
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| Umfang: | 16 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 08.11.2023 |
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| Titel Quelle: | Enthalten in: Expert systems with applications |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1990 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 208(2022) vom: Dez., Artikel-ID 118199, Seite 1-16 |
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| Abstract: | Acquiring a functional comprehension of the deregulation of cell signaling networks in disease allows progress in the development of new therapies and drugs. Computational models are becoming increasingly popular as a systematic tool to analyze the functioning of complex biochemical networks, such as those involved in cell signaling. CellNOpt is a framework to build predictive logic-based models of signaling pathways by training a prior knowledge network to biochemical data obtained from perturbation experiments. This training can be formulated as an optimization problem that can be solved using metaheuristics. However, the genetic algorithm used so far in CellNOpt presents limitations in terms of execution time and quality of solutions when applied to large instances. Thus, in order to overcome those issues, in this paper we propose the use of a method based on ant colony optimization, adapted to the problem at hand and parallelized using a hybrid approach. The performance of this novel method is illustrated with several challenging benchmark problems in the study of new therapies for liver cancer. |
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| DOI: | doi:10.1016/j.eswa.2022.118199 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.eswa.2022.118199 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0957417422013586 |
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| | DOI: https://doi.org/10.1016/j.eswa.2022.118199 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Ant colony optimization |
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| | Cell signaling network |
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| | High performance computing |
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| | Metaheuristics |
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| | MPI |
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| | OpenMP |
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| K10plus-PPN: | 1831275015 |
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| Verknüpfungen: | → Zeitschrift |
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Parallel ant colony optimization for the training of cell signaling networks / Gonzalez, Patricia [VerfasserIn]; 20 July 2022 (Online-Ressource)
