The role of iron in chronic inflammatory diseases

• Verfasst von: Marques, Oriana [VerfasserIn]
• Verfasst von: Weiss, Günter [VerfasserIn]
• Verfasst von: Muckenthaler, Martina [VerfasserIn]
• Titel: The role of iron in chronic inflammatory diseases
• Titelzusatz: from mechanisms to treatment options in anemia of inflammation
• Verf.angabe: Oriana Marques, Günter Weiss, and Martina U. Muckenthaler
• E-Jahr: 2022
• Jahr: November 10, 2022
• Umfang: 13 S.
• Fussnoten: Gesehen am 08.11.2023
• Titel Quelle: Enthalten in: Blood
• Ort Quelle: Washington, DC : American Society of Hematology, 1946
• Jahr Quelle: 2022
• Band/Heft Quelle: 140(2022), 19 vom: Nov., Seite 2011-2023
• ISSN Quelle: 1528-0020
• DOI: doi:10.1182/blood.2021013472
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1831279231

Abstract

Anemia of inflammation (AI) is a highly prevalent comorbidity in patients affected by chronic inflammatory disorders, such as chronic kidney disease, inflammatory bowel disease, or cancer, that negatively affect disease outcome and quality of life. The pathophysiology of AI is multifactorial, with inflammatory hypoferremia and iron-restricted erythropoiesis playing a major role in the context of disease-specific factors. Here, we review the recent progress in our understanding of the molecular mechanisms contributing to iron dysregulation in AI, the impact of hypoferremia and anemia on the course of the underlying disease, and (novel) therapeutic strategies applied to treat AI.