| |  Online-Ressource |
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| Verfasst von: | Sekar, Revathi [VerfasserIn]  |
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| | Motzler, Karsten [VerfasserIn] |
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| | Kwon, Yun [VerfasserIn] |
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| | Novikoff, Aaron [VerfasserIn] |
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| | Jülg, Julia [VerfasserIn] |
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| | Najafi, Bahar [VerfasserIn] |
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| | Wang, Surui [VerfasserIn] |
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| | Warnke, Anna-Luisa [VerfasserIn] |
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| | Seitz, Susanne [VerfasserIn] |
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| | Hass, Daniela [VerfasserIn] |
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| | Gancheva, Sofiya [VerfasserIn] |
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| | Kahl, Sabine [VerfasserIn] |
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| | Yang, Bin [VerfasserIn] |
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| | Finan, Brian [VerfasserIn] |
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| | Schwarz, Kathrin [VerfasserIn] |
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| | Okun, Jürgen G. [VerfasserIn] |
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| | Roden, Michael [VerfasserIn] |
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| | Blüher, Matthias [VerfasserIn] |
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| | Müller, Timo D. [VerfasserIn] |
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| | Krahmer, Natalie [VerfasserIn] |
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| | Behrends, Christian [VerfasserIn] |
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| | Plettenburg, Oliver [VerfasserIn] |
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| | Miaczynska, Marta [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| | Zeigerer, Anja [VerfasserIn] |
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| Titel: | Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes |
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| Verf.angabe: | Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg, Bahar Najafi, Surui Wang, Anna-Luisa Warnke, Susanne Seitz, Daniela Hass, Sofiya Gancheva, Sabine Kahl, Bin Yang, Brian Finan, Kathrin Schwarz, Juergen G. Okun, Michael Roden, Matthias Blüher, Timo D. Müller, Natalie Krahmer, Christian Behrends, Oliver Plettenburg, Marta Miaczynska, Stephan Herzig, and Anja Zeigerer |
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| E-Jahr: | 2022 |
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| Jahr: | 14 October 2022 |
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| Umfang: | 28 S. |
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| Fussnoten: | Dateiversion vom: 1. November 2022 ; Gesehen am 18.01.2023 |
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| Titel Quelle: | Enthalten in: Cell metabolism |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2005 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 34(2022), 11, Seite 1824-1842, e1-e9 |
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| ISSN Quelle: | 1932-7420 |
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| Abstract: | During mammalian energy homeostasis, the glucagon receptor (Gcgr) plays a key role in regulating both glucose and lipid metabolisms. However, the mechanisms by which these distinct signaling arms are differentially regulated remain poorly understood. Using a Cy5-glucagon agonist, we show that the endosomal protein Vps37a uncouples glucose production from lipid usage downstream of Gcgr signaling by altering intracellular receptor localization. Hepatocyte-specific knockdown of Vps37a causes an accumulation of Gcgr in endosomes, resulting in overactivation of the cAMP/PKA/p-Creb signaling pathway to gluconeogenesis without affecting β-oxidation. Shifting the receptor back to the plasma membrane rescues the differential signaling and highlights the importance of the spatiotemporal localization of Gcgr for its metabolic effects. Importantly, since Vps37a knockdown in animals fed with a high-fat diet leads to hyperglycemia, although its overexpression reduces blood glucose levels, these data reveal a contribution of endosomal signaling to metabolic diseases that could be exploited for treatments of type 2 diabetes. |
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| DOI: | doi:10.1016/j.cmet.2022.09.022 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cmet.2022.09.022 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1550413122004120 |
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| | DOI: https://doi.org/10.1016/j.cmet.2022.09.022 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | diabetes |
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| | endosomal trafficking and signaling |
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| | ESCRTs |
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| | glucagon receptor biology and signaling |
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| | liver metabolism |
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| K10plus-PPN: | 183132833X |
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| Verknüpfungen: | → Zeitschrift |
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Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes / Sekar, Revathi [VerfasserIn]; 14 October 2022 (Online-Ressource)
