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| Verfasst von: | Lurz, Eberhard [VerfasserIn]  |
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| | Lenz, Dominic [VerfasserIn] |
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| | Bufler, Philip [VerfasserIn] |
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| | Fichtner, Alexander [VerfasserIn] |
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| | Henning, Stephan [VerfasserIn] |
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| | Jankofsky, Martin [VerfasserIn] |
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| | Kathemann, Simone [VerfasserIn] |
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| | Melter, Michael [VerfasserIn] |
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| | Oh, Jun [VerfasserIn] |
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| | Pfister, Eva Doreen [VerfasserIn] |
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| | Sturm, Ekkehard [VerfasserIn] |
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| | Knoppke, Birgit [VerfasserIn] |
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| | Lainka, Elke [VerfasserIn] |
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| Titel: | The recent outbreak of acute severe hepatitis in children of unknown origin - what is known so far |
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| Verf.angabe: | Eberhard Lurz, Dominic Lenz, Philip Bufler, Alexander Fichtner, Stephan Henning, Martin Jankofsky, Simone Kathemann, Michael Melter, Jun Oh, Eva Doreen Pfister, Ekkehard Sturm, Birgit Knoppke, Elke Lainka |
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| E-Jahr: | 2022 |
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| Jahr: | [October 2022] |
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| Umfang: | 2 S. |
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| Fussnoten: | Gesehen am 18.01.2023 |
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| Titel Quelle: | Enthalten in: Journal of hepatology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1985 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 77(2022), 4, Seite 1214-1215 |
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| ISSN Quelle: | 1600-0641 |
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| Abstract: | Recent studies have reported that pediatric acute liver failure of unknown origin is immune-mediated, with CD8+ T cells playing a key role. Moreover, investigation of superantigen-mediated T-cell activation by the SARS-CoV-2 spike protein in pediatric severe acute hepatitis is needed in the context of the proposed mechanism of multisystem inflammatory syndrome in children (MIS-C). We investigated the immunological characteristics of a Japanese pediatric patient with severe acute hepatitis post SARS-CoV-2 infection. The patient demonstrated autoimmune hepatitis-like liver histology with CD8+ lymphocyte-predominant infiltration. There was Th1-type immune skewing, including remarkable peripheral CD8+ T-cell activation and a skewed T cell receptor repertoire. We also found elevated plasma levels of the anti-SARS-CoV-2 spike-specific IgG antibody, and the titer peaked after treatment, as seen with MIS-C. These findings support that immunological activation involving SARS-CoV-2 spike protein plays a crucial role in a pediatric patient with acute severe hepatitis post SARS-CoV-2 infection. |
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| DOI: | doi:10.1016/j.jhep.2022.05.039 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jhep.2022.05.039 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0168827822003634 |
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| | DOI: https://doi.org/10.1016/j.jhep.2022.05.039 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1831340682 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ recent outbreak of acute severe hepatitis in children of unknown origin - what is known so far / Lurz, Eberhard [VerfasserIn]; [October 2022] (Online-Ressource)
