Health behavior and cancer prevention among adults with Li-Fraumeni syndrome and relatives in Germany

• Verfasst von: Nees, Juliane [VerfasserIn]
• Verfasst von: Kiermeier, Senta [VerfasserIn]
• Verfasst von: Struewe, Farina [VerfasserIn]
• Verfasst von: Keymling, Myriam [VerfasserIn]
• Verfasst von: Maatouk, Imad [VerfasserIn]
• Verfasst von: Kratz, Christian P. [VerfasserIn]
• Verfasst von: Schott, Sarah [VerfasserIn]
• Titel: Health behavior and cancer prevention among adults with Li-Fraumeni syndrome and relatives in Germany
• Titelzusatz: a cohort description
• Verf.angabe: Juliane Nees, Senta Kiermeier, Farina Struewe, Myriam Keymling, Imad Maatouk, Christian P. Kratz and Sarah Schott
• E-Jahr: 2022
• Jahr: 15 October 2022
• Umfang: 11 S.
• Fussnoten: Gesehen am 18.01.2023
• Titel Quelle: Enthalten in: Current oncology
• Ort Quelle: Toronto, Ontario : Multimed, 2005
• Jahr Quelle: 2022
• Band/Heft Quelle: 29(2022), 10, Seite 7768-7778
• ISSN Quelle: 1718-7729
• DOI: doi:10.3390/curroncol29100614
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cancer predisposition
• Sach-SW: cancer prevention
• Sach-SW: Li-Fraumeni syndrome
• Sach-SW: MEDAS
• Sach-SW: pathogenic <i>TP53</i> germline variant
• Sach-SW: physical activity
• Sach-SW: SF-12
• K10plus-PPN: 1831390728
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Li-Fraumeni-syndrome (LFS) is a rare, highly penetrant cancer predisposition syndrome (CPS) caused by pathogenic variants (PVs) in TP53. Physical activity (PA) and a Mediterranean diet lead to cancer reduction or survival benefits and increased quality of life (QoL), but this is yet unstudied among LFS. TP53 PV carriers (PVC) and their relatives were questioned on dietary patterns (Mediterranean Diet Adherence Screener), PA (Freiburg Questionnaire), QoL (Short-form-Health-Survey-12), smoking, alcohol consumption and perception of cancer risk in a German bi-centric study from March 2020-June 2021. The study enrolled 70 PVC and 43 relatives. Women compared to men (6.49 vs. 5.38, p = 0.005) and PVC to relatives (6.59 vs. 5.51; p = 0.006) showed a healthier diet, associated with participation in surveillance (p = 0.04) and education (diet p = 0.02 smoking p = 0.0003). Women smoked less (2.91 vs. 5.91 packyears; p = 0.03), psychological well-being was higher among men (SF-12: males 48.06 vs. females 41.94; p = 0.004). PVC rated their own cancer risk statistically higher than relatives (72% vs. 38%, p < 0.001) however, cancer risk of the general population was rated lower (38% vs. 70%, p < 0.001). A relative’s cancer-related death increased the estimated personal cancer risk (p = 0.01). The possibilities of reducing cancer through self-determined health behavior among PVC and relatives has not yet been exhausted. Educating families with a CPS on cancer-preventive behavior requires further investigation with regard to acceptance and real-life implementation.