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| Verfasst von: | Everlien, Isabelle [VerfasserIn]  |
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| | Yen, Ting-Yun [VerfasserIn] |
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| | Liu, Yu-Chao [VerfasserIn] |
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| | Di Marco, Barbara [VerfasserIn] |
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| | Vázquez-Marín, Javier [VerfasserIn] |
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| | Centanin, Lázaro [VerfasserIn] |
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| | Alfonso, Julieta [VerfasserIn] |
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| | Monyer, Hannah [VerfasserIn] |
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| Titel: | Diazepam binding inhibitor governs neurogenesis of excitatory and inhibitory neurons during embryonic development via GABA signaling |
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| Verf.angabe: | Isabelle Everlien, Ting-Yun Yen, Yu-Chao Liu, Barbara Di Marco, Javier Vázquez-Marín, Lázaro Centanin, Julieta Alfonso, Hannah Monyer |
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| E-Jahr: | 2022 |
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| Jahr: | 5 October 2022 |
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| Umfang: | 22 S. |
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| Fussnoten: | Online verfügbar 22 August 2022, Artikelversion 5 Oktober 2022 ; Gesehen am 18.01.2023 |
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| Titel Quelle: | Enthalten in: Neuron |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1988 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 110(2022), 19, Seite 3139-3153.e6 |
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| ISSN Quelle: | 1097-4199 |
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| Abstract: | Of the neurotransmitters that influence neurogenesis, gamma-aminobutyric acid (GABA) plays an outstanding role, and GABA receptors support non-synaptic signaling in progenitors and migrating neurons. Here, we report that expression levels of diazepam binding inhibitor (DBI), an endozepine that modulates GABA signaling, regulate embryonic neurogenesis, affecting the long-term outcome regarding the number of neurons in the postnatal mouse brain. We demonstrate that DBI is highly expressed in radial glia and intermediate progenitor cells in the germinal zones of the embryonic mouse brain that give rise to excitatory and inhibitory cells. The mechanism by which DBI controls neurogenesis involves its action as a negative allosteric modulator of GABA-induced currents on progenitor cells that express GABAA receptors containing γ2 subunits. DBI’s modulatory effect parallels that of GABAA-receptor-mediating signaling in these cells in the proliferative areas, reflecting the tight control that DBI exerts on embryonic neurogenesis. |
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| DOI: | doi:10.1016/j.neuron.2022.07.022 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neuron.2022.07.022 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0896627322006675 |
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| | DOI: https://doi.org/10.1016/j.neuron.2022.07.022 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | embryonic neurogenesis |
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| | endozepine |
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| | GABAA receptor |
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| | germinal zones |
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| K10plus-PPN: | 1831406780 |
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| Verknüpfungen: | → Zeitschrift |
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Diazepam binding inhibitor governs neurogenesis of excitatory and inhibitory neurons during embryonic development via GABA signaling / Everlien, Isabelle [VerfasserIn]; 5 October 2022 (Online-Ressource)
