| |  Online-Ressource |
|---|
| Verfasst von: | Wagner, Claudius [VerfasserIn]  |
|---|
| | Balázs, Anita [VerfasserIn] |
|---|
| | Schatterny, Jolanthe [VerfasserIn] |
|---|
| | Zhou-Suckow, Zhe [VerfasserIn] |
|---|
| | Duerr, Julia [VerfasserIn] |
|---|
| | Schultz, Carsten [VerfasserIn] |
|---|
| | Mall, Marcus A. [VerfasserIn] |
|---|
| Titel: | Genetic deletion of Mmp9 does not reduce airway inflammation and structural lung damage in mice with cystic fibrosis-like lung disease |
|---|
| Verf.angabe: | Claudius Wagner, Anita Balázs, Jolanthe Schatterny, Zhe Zhou-Suckow, Julia Duerr, Carsten Schultz and Marcus A. Mall |
|---|
| E-Jahr: | 2022 |
|---|
| Jahr: | 2 November 2022 |
|---|
| Umfang: | 13 S. |
|---|
| Fussnoten: | Gesehen am 23.01.2023 |
|---|
| Titel Quelle: | Enthalten in: International journal of molecular sciences |
|---|
| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
|---|
| Jahr Quelle: | 2022 |
|---|
| Band/Heft Quelle: | 23(2022), 21, Artikel-ID 13405, Seite 1-13 |
|---|
| ISSN Quelle: | 1422-0067 |
|---|
| | 1661-6596 |
|---|
| Abstract: | Elevated levels of matrix metalloprotease 9 (MMP-9) and neutrophil elastase (NE) are associated with bronchiectasis and lung function decline in patients with cystic fibrosis (CF). MMP-9 is a potent extracellular matrix-degrading enzyme which is activated by NE and has been implicated in structural lung damage in CF. However, the role of MMP-9 in the in vivo pathogenesis of CF lung disease is not well understood. Therefore, we used β-epithelial Na+ channel-overexpressing transgenic (βENaC-Tg) mice as a model of CF-like lung disease and determined the effect of genetic deletion of Mmp9 (Mmp9-/-) on key aspects of the pulmonary phenotype. We found that MMP-9 levels were elevated in the lungs of βENaC-Tg mice compared with wild-type littermates. Deletion of Mmp9 had no effect on spontaneous mortality, inflammatory markers in bronchoalveolar lavage, goblet cell metaplasia, mucus hypersecretion and emphysema-like structural lung damage, while it partially reduced mucus obstruction in βENaC-Tg mice. Further, lack of Mmp9 had no effect on increased inspiratory capacity and increased lung compliance in βENaC-Tg mice, whereas both lung function parameters were improved with genetic deletion of NE. We conclude that MMP-9 does not play a major role in the in vivo pathogenesis of CF-like lung disease in mice. |
|---|
| DOI: | doi:10.3390/ijms232113405 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms232113405 |
|---|
| | Volltext: https://www.mdpi.com/1422-0067/23/21/13405 |
|---|
| | DOI: https://doi.org/10.3390/ijms232113405 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | airway inflammation |
|---|
| | lung damage |
|---|
| | matrix metalloproteinase 9 |
|---|
| | neutrophil elastase |
|---|
| K10plus-PPN: | 1831770016 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Genetic deletion of Mmp9 does not reduce airway inflammation and structural lung damage in mice with cystic fibrosis-like lung disease / Wagner, Claudius [VerfasserIn]; 2 November 2022 (Online-Ressource)
