Glaucoma-like optic neuropathy in patients with intracranial tumours

• Verfasst von: Qu, Yuanzhen [VerfasserIn]
• Verfasst von: Wang, Ya Xing [VerfasserIn]
• Verfasst von: Xu, Liang [VerfasserIn]
• Verfasst von: Zhang, Liwei [VerfasserIn]
• Verfasst von: Zhang, Junting [VerfasserIn]
• Verfasst von: Zhang, Jianguo [VerfasserIn]
• Verfasst von: Wang, Lina [VerfasserIn]
• Verfasst von: Yang, Liu [VerfasserIn]
• Verfasst von: Yang, Anchao [VerfasserIn]
• Verfasst von: Wang, Jian [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Titel: Glaucoma-like optic neuropathy in patients with intracranial tumours
• Verf.angabe: Yuanzhen Qu, Ya Xing Wang, Liang Xu, Liwei Zhang, Junting Zhang, Jianguo Zhang, Lina Wang, Liu Yang, Anchao Yang, Jian Wang and Jost B. Jonas
• E-Jahr: 2011
• Jahr: 18 February 2011
• Umfang: 6 S.
• Fussnoten: Gesehen am 23.01.2023
• Titel Quelle: Enthalten in: Acta ophthalmologica
• Ort Quelle: Oxford : Blackwell, 2008
• Jahr Quelle: 2011
• Band/Heft Quelle: 89(2011), 5, Seite e428-e433
• ISSN Quelle: 1755-3768
• DOI: doi:10.1111/j.1755-3768.2011.02118.x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adenoma
• Sach-SW: Adolescent
• Sach-SW: Adult
• Sach-SW: Aged
• Sach-SW: Brain Neoplasms
• Sach-SW: Child
• Sach-SW: Child, Preschool
• Sach-SW: Female
• Sach-SW: Glaucoma
• Sach-SW: Humans
• Sach-SW: Intracranial Pressure
• Sach-SW: Male
• Sach-SW: Meningeal Neoplasms
• Sach-SW: Meningioma
• Sach-SW: Middle Aged
• Sach-SW: Optic Disk
• Sach-SW: Optic Nerve Diseases
• Sach-SW: Pituitary Neoplasms
• Sach-SW: Prevalence
• Sach-SW: Retrospective Studies
• Sach-SW: Sella Turcica
• Sach-SW: Young Adult
• K10plus-PPN: 1831792664

Abstract

PURPOSE: To examine frequency and associated factors of glaucoma-like appearance of the optic nerve head in patients with intrasellar, suprasellar or parasellar tumours. - METHODS: This retrospective clinical observational study included patients who were consecutively treated for intrasellar tumours (n = 143), suprasellar tumours (n = 321), parasellar tumours (n = 36) or retrosellar tumour (n = 1), and all of whom had undergone fundus photography and full-threshold visual field examination. The tumour spectrum included 336 pituitary gland tumours, 32 meningiomas, 89 craniopharyngiomas, 9 chiasmal gliomas and 35 other types of tumours or lesions. An age-matched control group was formed from the population-based Beijing Eye Study. Using fundus photographs and visual field examinations, glaucoma was defined by a neuroretinal rim shape not following the ISNT rule (Disc glaucoma group) and by an abnormal rim shape plus glaucoma-like visual field defects (Field glaucoma group). Type and size of the tumours were assessed on neuroradiological images. - RESULTS: Five-hundred and one patients fulfilled the inclusion criteria. Disc glaucoma and Field glaucoma were detected significantly more frequently in the study population [34 (6.8%) patients and 31 (6.3%) patients, respectively] than in the population-based control group of the same ethnicity (1.3% ± 0.5%; p < 0.001). In multivariate analysis, presence of Disc glaucoma [odds ratio (OR) = 2.64; p = 0.016] and presence of Field glaucoma (OR = 3.01; p = 0.027) were significantly associated with tumour location [suprasellar > parasellar > intrasellar]. The same held true for tumour width (OR = 1.08; p = 0.002; and OR = 1.08; p = 0.003, respectively). - CONCLUSIONS: Large perisellar tumours were associated with a glaucoma-like appearance of the optic nerve head in eyes. It may diagnostically and pathogenetically be of importance.