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| Verfasst von: | Lau, Benjamin [VerfasserIn]  |
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| | Beine-Golovchuk, Olga [VerfasserIn] |
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| | Kornprobst, Markus [VerfasserIn] |
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| | Cheng, Jingdong [VerfasserIn] |
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| | Kressler, Dieter [VerfasserIn] |
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| | Jády, Beáta [VerfasserIn] |
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| | Kiss, Tamás [VerfasserIn] |
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| | Beckmann, Roland [VerfasserIn] |
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| | Hurt, Ed [VerfasserIn] |
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| Titel: | Cms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release |
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| Verf.angabe: | Benjamin Lau, Olga Beine-Golovchuk, Markus Kornprobst, Jingdong Cheng, Dieter Kressler, Beáta Jády, Tamás Kiss, Roland Beckmann, Ed Hurt |
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| E-Jahr: | 2022 |
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| Jahr: | 22 November 2022 |
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| Umfang: | 22 S. |
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| Fussnoten: | Gesehen am 23.01.2023 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 41(2022), 8, Artikel-ID 111684, Seite 1-22 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Ribosome synthesis begins in the nucleolus with 90S pre-ribosome construction, but little is known about how the many different snoRNAs that modify the pre-rRNA are timely guided to their target sites. Here, we report a role for Cms1 in such a process. Initially, we discovered CMS1 as a null suppressor of a nop14 mutant impaired in Rrp12-Enp1 factor recruitment to the 90S. Further investigations detected Cms1 at the 18S rRNA 3′ major domain of an early 90S that carried H/ACA snR83, which is known to guide pseudouridylation at two target sites within the same subdomain. Cms1 co-precipitates with many 90S factors, but Rrp12-Enp1 encircling the 3′ major domain in the mature 90S is decreased. We suggest that Cms1 associates with the 3′ major domain during early 90S biogenesis to restrict premature Rrp12-Enp1 binding but allows snR83 to timely perform its modification role before the next 90S assembly steps coupled with Cms1 release take place. |
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| DOI: | doi:10.1016/j.celrep.2022.111684 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2022.111684 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722015583 |
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| | DOI: https://doi.org/10.1016/j.celrep.2022.111684 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 90S pre-ribosome |
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| | H/ACA |
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| | pre-rRNA |
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| | pseudouridylation |
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| | ribosome assembly |
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| | RNA modification |
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| | snoRNA |
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| | suppressor |
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| | yeast |
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| K10plus-PPN: | 1831796872 |
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| Verknüpfungen: | → Zeitschrift |
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Cms1 coordinates stepwise local 90S pre-ribosome assembly with timely snR83 release / Lau, Benjamin [VerfasserIn]; 22 November 2022 (Online-Ressource)
