Effect of anemia on the prognosis of patients with ventricular tachyarrhythmias

• Verfasst von: Weidner, Kathrin [VerfasserIn]
• Verfasst von: Zworowsky, Max von [VerfasserIn]
• Verfasst von: Schupp, Tobias [VerfasserIn]
• Verfasst von: Hoppner, Jorge [VerfasserIn]
• Verfasst von: Kittel, Maximilian [VerfasserIn]
• Verfasst von: Rusnak, Jonas [VerfasserIn]
• Verfasst von: Kim, Seung‑Hyun [VerfasserIn]
• Verfasst von: Abumayyaleh, Mohammad S. A. [VerfasserIn]
• Verfasst von: Borggrefe, Martin [VerfasserIn]
• Verfasst von: Barth, Christian [VerfasserIn]
• Verfasst von: Ellguth, Dominik [VerfasserIn]
• Verfasst von: Taton, Gabriel [VerfasserIn]
• Verfasst von: Reiser, Linda [VerfasserIn]
• Verfasst von: Kern-Bollow, Armin [VerfasserIn]
• Verfasst von: Große Meininghaus, Dirk [VerfasserIn]
• Verfasst von: Bertsch, Thomas [VerfasserIn]
• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Behnes, Michael [VerfasserIn]
• Titel: Effect of anemia on the prognosis of patients with ventricular tachyarrhythmias
• Verf.angabe: Kathrin Weidner, MD, Max von Zworowsky, MS, Tobias Schupp, MD, Jorge Hoppner, MD, Maximilian Kittel, MD, Jonas Rusnak, MD, Seung-hyun Kim, MD, Mohammad Abumayyaleh, MD, Martin Borggrefe, MD, Christian Barth, MD, Dominik Ellguth, MD, Gabriel Taton, MD, Linda Reiser, MS, Armin Bollow, MD, Dirk Groe Meininghaus, MD, Thomas Bertsch, MD, Ibrahim El-Battrawy, MD, Ibrahim Akin, MD, and Michael Behnes, MD
• E-Jahr: 2021
• Jahr: 1 September 2021
• Fussnoten: Gesehen am 24.01.20023
• Titel Quelle: Enthalten in: The American journal of cardiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1958
• Jahr Quelle: 2021
• Band/Heft Quelle: 154(2021), Seite 54-62
• ISSN Quelle: 1879-1913
• DOI: doi:10.1016/j.amjcard.2021.05.045
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1831891565

Abstract

This study evaluates the prognostic impact of anemia in patients presenting with ventricular tachyarrhythmias. The present longitudinal, observational, registry-based, monocentric cohort study included retrospectively all consecutive patients presenting with ventricular tachyarrhythmias on admission from 2002 to 2016. Anemic patients (hemoglobin levels <12.0 g/dl) were compared with non-anemic patients (hemoglobin levels ≥12.0 g/dl). The primary endpoint was all-cause mortality at 2.5 years. Secondary endpoints were cardiac death at 24 hours, all-cause mortality at index hospitalization, and the composite endpoint of cardiac death at 24 hours, recurrent ventricular tachyarrhythmias, and appropriate ICD therapies at 2.5 years. A total of 2,184 consecutive patients were included, of whom 30% were anemic and 70% non-anemic. Anemia was associated with the primary endpoint of all-cause mortality at 2.5 years (65% vs 29%, p = 0.001; HR = 2.441; 95% CI 2.086 to 2.856), cardiac death at 24 hours (26% vs 11%, p = 0.001), all-cause mortality at index hospitalization (45% vs 20%, p = 0.001), and the composite endpoint (35% vs 27%, p = 0.001; HR = 2.923; 95% CI 2.564 to 4.366). After multivariable adjustment, anemia was no longer associated with the composite endpoint. Predictors of adverse prognosis for anemics were CKD (HR = 2.191), LVEF <35% (HR = 1.651), cardiogenic shock (HR = 1.591), CPR (HR = 1.460), male gender (HR = 1.379), and age (HR = 1.017). In conclusion, anemic patients presenting with ventricular tachyarrhythmias were associated with increased long-term mortality at 2.5 years but not with the composite arrhythmic endpoint at 2.5 years. Predictors of adverse prognosis at 2.5 years were CKD, LVEF <35%, cardiogenic shock, CPR, male gender, and age.