| |  Online-Ressource |
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| Verfasst von: | Kilian, Michael [VerfasserIn]  |
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| | Sheinin, Ron [VerfasserIn] |
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| | Tan, Chin Leng [VerfasserIn] |
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| | Friedrich, Mirco [VerfasserIn] |
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| | Krämer, Christopher [VerfasserIn] |
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| | Kaminitz, Ayelet [VerfasserIn] |
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| | Sanghvi, Khwab [VerfasserIn] |
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| | Lindner, Katharina [VerfasserIn] |
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| | Chih, Yu-Chan [VerfasserIn] |
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| | Cichon, Frederik [VerfasserIn] |
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| | Richter, Benjamin [VerfasserIn] |
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| | Jung, Stefanie [VerfasserIn] |
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| | Jähne, Kristine [VerfasserIn] |
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| | Ratliff, Miriam [VerfasserIn] |
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| | Prins, Robert M. [VerfasserIn] |
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| | Etminan, Nima [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Madi, Asaf [VerfasserIn] |
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| | Bunse, Lukas [VerfasserIn] |
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| | Platten, Michael [VerfasserIn] |
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| Titel: | MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors |
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| Verf.angabe: | Michael Kilian, Ron Sheinin, Chin Leng Tan, Mirco Friedrich, Christopher Krämer, Ayelet Kaminitz, Khwab Sanghvi, Katharina Lindner, Yu-Chan Chih, Frederik Cichon, Benjamin Richter, Stefanie Jung, Kristine Jähne, Miriam Ratliff, Robert M. Prins, Nima Etminan, Andreas von Deimling, Wolfgang Wick, Asaf Madi, Lukas Bunse, and Michael Platten |
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| E-Jahr: | 2023 |
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| Jahr: | 13 January 2023 |
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| Umfang: | 27 S. |
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| Fussnoten: | Online verfügbar 12 January 2023, Version des Artikels 13 February 2023 ; Gesehen am 26.01.2023 |
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| Titel Quelle: | Enthalten in: Cancer cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2002 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 41(2023), 2, Seite 235-251 |
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| ISSN Quelle: | 1878-3686 |
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| Abstract: | Cancer immunotherapy critically depends on fitness of cytotoxic and helper T cell responses. Dysfunctional cytotoxic T cell states in the tumor microenvironment (TME) are a major cause of resistance to immunotherapy. Intratumoral myeloid cells, particularly blood-borne myeloids (bbm), are key drivers of T cell dysfunction in the TME. We show here that major histocompatibility complex class II (MHCII)-restricted antigen presentation on bbm is essential to control the growth of brain tumors. Loss of MHCII on bbm drives dysfunctional intratumoral tumor-reactive CD8+ T cell states through increased chromatin accessibility and expression of Tox, a critical regulator of T cell exhaustion. Mechanistically, MHCII-dependent activation of CD4+ T cells restricts myeloid-derived osteopontin that triggers a chronic activation of NFAT2 in tumor-reactive CD8+ T cells. In summary, we provide evidence that MHCII-restricted antigen presentation on bbm is a key mechanism to directly maintain functional cytotoxic T cell states in brain tumors. |
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| DOI: | doi:10.1016/j.ccell.2022.12.007 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ccell.2022.12.007 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1535610822005931 |
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| | DOI: https://doi.org/10.1016/j.ccell.2022.12.007 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CD8 T cell dysfunction |
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| | glioblastoma |
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| | glioma |
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| | macrophages |
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| | MHC class II |
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| | microenvironment |
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| | myeloid cells |
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| | NFAT |
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| | osteopontin |
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| | TOX |
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| K10plus-PPN: | 1832484084 |
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| Verknüpfungen: | → Zeitschrift |
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MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors / Kilian, Michael [VerfasserIn]; 13 January 2023 (Online-Ressource)
