| |  Online-Ressource |
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| Verfasst von: | Ammann, Nadine [VerfasserIn]  |
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| | Schwietzer, Yasmin F. [VerfasserIn] |
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| | Meß, Christian [VerfasserIn] |
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| | Stadler, Julia-Christina [VerfasserIn] |
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| | Geidel, Glenn [VerfasserIn] |
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| | Kött, Julian [VerfasserIn] |
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| | Pantel, Klaus [VerfasserIn] |
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| | Schneider, Stefan W. [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Bauer, Alexander [VerfasserIn] |
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| | Gebhardt, Christoffer [VerfasserIn] |
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| Titel: | Activated eosinophils predict longer progression-free survival under immune checkpoint inhibition in melanoma |
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| Verf.angabe: | Nadine L. Ammann, Yasmin F. Schwietzer, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Julian Kött, Klaus Pantel, Stefan W. Schneider, Jochen Utikal, Alexander T. Bauer and Christoffer Gebhardt |
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| E-Jahr: | 2022 |
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| Jahr: | 18 November 2022 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 26.01.2023 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 14(2022), 22, Artikel-ID 5676, Seite 1-19 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Immune checkpoint inhibition (ICI) has yielded remarkable results in prolonging survival of metastatic melanoma patients but only a subset of individuals treated respond to therapy. Success of ICI treatment appears to depend on the number of tumor-infiltrating effector T-cells, which are known to be influenced by activated eosinophils. To verify the co-occurrence of activated eosinophils and T-cells in melanoma, immunofluorescence was performed in 285 primary or metastatic tumor tissue specimens from 118 patients. Moreover, eosinophil counts and activity markers such as eosinophil cationic protein (ECP) and eosinophil peroxidase (EPX) were measured in the serum before therapy start and before the 4th infusion of ICI in 45 metastatic unresected melanoma patients. We observed a positive correlation between increased tumor-infiltrating eosinophils and T-cells associated with delayed melanoma progression. High baseline levels of eosinophil count, serum ECP and EPX were linked to prolonged progression-free survival in metastatic melanoma. Our data provide first indications that activated eosinophils are related to the T-cell-inflamed tumor microenvironment and could be considered as potential future prognostic biomarkers in melanoma. |
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| DOI: | doi:10.3390/cancers14225676 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cancers14225676 |
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| | Volltext: https://www.mdpi.com/2072-6694/14/22/5676 |
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| | DOI: https://doi.org/10.3390/cancers14225676 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomarker |
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| | ECP |
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| | eosinophils |
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| | EPX |
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| | immune checkpoint inhibition |
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| | inflammation |
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| | melanoma |
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| | T-cells |
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| | tumor microenvironment |
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| K10plus-PPN: | 183250798X |
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| Verknüpfungen: | → Zeitschrift |
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Activated eosinophils predict longer progression-free survival under immune checkpoint inhibition in melanoma / Ammann, Nadine [VerfasserIn]; 18 November 2022 (Online-Ressource)
