Reirradiation with intensity-modulated radiotherapy in recurrent head and neck cancer

• Verfasst von: Zwicker, Felix [VerfasserIn]
• Verfasst von: Röder, Falk [VerfasserIn]
• Verfasst von: Hauswald, Henrik [VerfasserIn]
• Verfasst von: Thieke, Christian [VerfasserIn]
• Verfasst von: Timke, Carmen [VerfasserIn]
• Verfasst von: Schlegel, Wolfgang [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Münter, Marc [VerfasserIn]
• Verfasst von: Huber, Peter E. [VerfasserIn]
• Titel: Reirradiation with intensity-modulated radiotherapy in recurrent head and neck cancer
• Verf.angabe: Felix Zwicker, Falk Roeder, Henrik Hauswald, Christian Thieke, Carmen Timke, Wolfgang Schlegel, Juergen Debus, Marc W. Münter, Peter E. Huber
• E-Jahr: 2011
• Jahr: 31 January 2011
• Umfang: 8 S.
• Fussnoten: Gesehen am 30.01.2023
• Titel Quelle: Enthalten in: Head & neck
• Ort Quelle: New York, NY [u.a.] : Wiley Interscience, 1979
• Jahr Quelle: 2011
• Band/Heft Quelle: 33(2011), 12, Seite 1695-1702
• ISSN Quelle: 1097-0347
• DOI: doi:10.1002/hed.21663
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: intensity-modulated radiotherapy
• Sach-SW: late toxicity
• Sach-SW: recurrent head and neck cancer
• Sach-SW: reirradiation
• Sach-SW: xerostomia
• K10plus-PPN: 1832648257

Abstract

Background: In this retrospective investigation we analyzed outcome and toxicity after intensity-modulated reirradiation of recurrent head and neck cancer. Methods Thirty-eight patients with local recurrent head and neck cancer were evaluated. The median dose of initial radiotherapy was 61 Gy. Reirradiation was carried out with step-and-shoot intensity-modulated radiotherapy (median dose: 49 Gy). Results Median overall survival was 17 months, and the 1- and 2-year overall survival rates were 63% and 34%. The 1- and 2-year local control rates were 57% and 53%. Distant spread occurred in 34%, and reirradiation induced considerable late toxicity in 21% of the patients. Thirty-two percent showed increased xerostomia after reirradiation. The risk for xerostomia was significantly higher for cumulative mean doses of ≥45 Gy to parotid glands. Considering median cumulative maximum doses of 53 Gy to the spinal cord and 63 Gy to the brainstem, no late toxicities were observed. Conclusions Reirradiation with intensity-modulated radiotherapy in recurrent head and neck cancer is feasible with acceptable toxicity and yields encouraging rates of local control and overall survival. - Methods: Thirty-eight patients with local recurrent head and neck cancer were evaluated. The median dose of initial radiotherapy was 61 Gy. Reirradiation was carried out with step-and-shoot intensity-modulated radiotherapy (median dose: 49 Gy). - Results: Median overall survival was 17 months, and the 1- and 2-year overall survival rates were 63% and 34%. The 1- and 2-year local control rates were 57% and 53%. Distant spread occurred in 34%, and reirradiation induced considerable late toxicity in 21% of the patients. Thirty-two percent showed increased xerostomia after reirradiation. The risk for xerostomia was significantly higher for cumulative mean doses of ≥45 Gy to parotid glands. Considering median cumulative maximum doses of 53 Gy to the spinal cord and 63 Gy to the brainstem, no late toxicities were observed. - Conclusions: Reirradiation with intensity-modulated radiotherapy in recurrent head and neck cancer is feasible with acceptable toxicity and yields encouraging rates of local control and overall survival.