Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Schelbert, Selina [VerfasserIn]   i
 Schindeldecker, Mario [VerfasserIn]   i
 Drebber, Uta [VerfasserIn]   i
 Witzel, Hagen Roland [VerfasserIn]   i
 Weinmann, Arndt [VerfasserIn]   i
 Dries, Volker [VerfasserIn]   i
 Schirmacher, Peter [VerfasserIn]   i
 Roth, Wilfried [VerfasserIn]   i
 Straub, Beate Katharina [VerfasserIn]   i
Titel:Lipid droplet-associated proteins Perilipin 1 and 2
Titelzusatz:molecular markers of steatosis and microvesicular steatotic foci in chronic Hepatitis C
Verf.angabe:Selina Schelbert, Mario Schindeldecker, Uta Drebber, Hagen Roland Witzel, Arndt Weinmann, Volker Dries, Peter Schirmacher, Wilfried Roth and Beate Katharina Straub
E-Jahr:2022
Jahr:7 December 2022
Umfang:20 S.
Fussnoten:Gesehen am 30.01.2023
Titel Quelle:Enthalten in: International journal of molecular sciences
Ort Quelle:Basel : Molecular Diversity Preservation International, 2000
Jahr Quelle:2022
Band/Heft Quelle:23(2022), 24 vom: Dez., Artikel-ID 15456, Seite 1-20
ISSN Quelle:1422-0067
 1661-6596
Abstract:Chronic infection with hepatitis C (HCV) is a major risk factor in the development of cirrhosis and hepatocellular carcinoma. Lipid metabolism plays a major role in the replication and deposition of HCV at lipid droplets (LDs). We have demonstrated the importance of LD-associated proteins of the perilipin family in steatotic liver diseases. Using a large collection of 231 human liver biopsies with HCV, perilipins 1 and 2 have been localized to LDs of hepatocytes that correlate with the degree of steatosis and specific HCV genotypes, but not significantly with the HCV viral load. Perilipin 1- and 2-positive microvesicular steatotic foci were observed in 36% of HCV liver biopsies, and also in chronic hepatitis B, autoimmune hepatitis and mildly steatotic or normal livers, but less or none were observed in normal livers of younger patients. Microvesicular steatotic foci did not frequently overlap with glycogenotic/clear cell foci as determined by PAS stain in serial sections. Steatotic foci were detected in all liver zones with slight architectural disarrays, as demonstrated by immunohistochemical glutamine synthetase staining of zone three, but without elevated Ki67-proliferation rates. In conclusion, microvesicular steatotic foci are frequently found in chronic viral hepatitis, but the clinical significance of these foci is so far not clear.
DOI:doi:10.3390/ijms232415456
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/ijms232415456
 Volltext: https://www.mdpi.com/1422-0067/23/24/15456
 DOI: https://doi.org/10.3390/ijms232415456
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:focal fatty change
 hepatitis B virus (HBV)
 hepatitis C virus (HCV)
 non-alcoholic steatohepatitis (NASH)
 PAT proteins
K10plus-PPN:1832678431
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69027736   QR-Code
zum Seitenanfang