Exploring biomarkers in routine diagnostics for the risk stratification of older patients in the Chest Pain Unit

• Verfasst von: Kunz, Anna Lisa [VerfasserIn]
• Verfasst von: Schönstein, Anton [VerfasserIn]
• Verfasst von: Bahrmann, Philipp [VerfasserIn]
• Verfasst von: Giannitsis, Evangelos [VerfasserIn]
• Verfasst von: Wahl, Hans-Werner [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Frey, Norbert [VerfasserIn]
• Verfasst von: Bahrmann, Anke [VerfasserIn]
• Titel: Exploring biomarkers in routine diagnostics for the risk stratification of older patients in the Chest Pain Unit
• Titelzusatz: a prospective cohort study
• Verf.angabe: Anna Lisa Kunz, Anton Schönstein, Philipp Bahrmann, Evangelos Giannitsis, Hans-Werner Wahl, Hugo A. Katus, Norbert Frey, Anke Bahrmann
• Jahr: 2022
• Umfang: 8 S.
• Fussnoten: Gesehen am 30.01.2023
• Titel Quelle: Enthalten in: BMJ open
• Ort Quelle: London : BMJ Publishing Group, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), 12, Artikel-ID e056674, Seite 1-8
• ISSN Quelle: 2044-6055
• DOI: doi:10.1136/bmjopen-2021-056674
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cardiology
• Sach-SW: geriatric medicine
• Sach-SW: risk management
• K10plus-PPN: 1832680711
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Objectives This study aims to estimate the association of the often, in daily clinical practice, used biological age-related biomarkers high-sensitivity troponin-T (hs-TnT), C reactive protein (CRP) and haemoglobin (Hb) with all-cause mortality for the purpose of older patient’s risk stratification in the emergency department (ED). - Design Exploratory, prospective cohort study with a follow-up at 2.5 years after recruitment started. For the predictors, data from the hospital files including the routinely applied biological age-related biomarkers hs-TnT, CRP and Hb were supplemented by a questionnaire. - Setting A cardiological ED, Chest Pain Unit, University Hospital Heidelberg, Germany. - Participants N=256 cardiological ED patients with a minimum age of 70 years and the capability to informed consent. - Primary outcome measures The primary outcome of this study was all-cause mortality which was assessed by requesting registry office information. - Results Among N=256 patients 63 died over the follow-up period. Positive results in each of the three biomarkers alone as well as the combination were associated with increased all-cause mortality at follow-up. The number of positive age-related biomarkers appeared to be strongly indicative of the risk of mortality, even when controlled for major confounders (age, sex, body mass index, creatinine clearance and comorbidity). - Conclusions In older ED patients, biomarkers explicitly related to biological ageing processes such as hs-TnT, CRP and Hb were to a certain degree independently of each other as well as combined associated with an increased risk of all-cause mortality. Thus, they may have the potential to be used to supplement the general risk stratification of older patients in the ED. Validation of the results in a large dataset is needed.