| |  Online-Ressource |
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| Verfasst von: | Lippmann, Kristina [VerfasserIn]  |
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| | Klaft, Zin-Juan [VerfasserIn] |
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| | Salar, Seda [VerfasserIn] |
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| | Hollnagel, Jan-Oliver [VerfasserIn] |
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| | Valero, Manuel [VerfasserIn] |
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| | Maslarova, Anna [VerfasserIn] |
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| Titel: | Status epilepticus induces chronic silencing of burster and dominance of regular firing neurons during sharp wave-ripples in the mouse subiculum |
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| Verf.angabe: | Kristina Lippmann, Zin-Juan Klaft, Seda Salar, Jan-Oliver Hollnagel, Manuel Valero, Anna Maslarova |
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| E-Jahr: | 2022 |
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| Jahr: | 24 November 2022 |
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| Umfang: | 16 S. |
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| Fussnoten: | Online verfügbar 21 November 2022, Artikelversion 24 November 2022 ; Gesehen am 31.01.2023 |
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| Titel Quelle: | Enthalten in: Neurobiology of disease |
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| Ort Quelle: | [Amsterdam] : Elsevier, 1994 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 175(2022) vom: Nov., Artikel-ID 105929, Seite 1-16 |
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| ISSN Quelle: | 1095-953X |
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| Abstract: | Sharp wave-ripples (SWRs) are hippocampal oscillations associated with memory consolidation. The subiculum, as the hippocampal output structure, ensures that hippocampal memory representations are transferred correctly to the consolidating neocortical regions. Because patients with temporal lobe epilepsy often develop memory deficits, we hypothesized that epileptic networks may disrupt subicular SWRs. We therefore investigated the impact of experimentally induced status epilepticus (SE) on subicular SWRs and contributing pyramidal neurons using electrophysiological recordings in mouse hippocampal slices. Subicular SWRs expressed hyperexcitable features post-SE, including increased ripple and unit activity. While regular firing neurons normally remain silent during SWRs, selective disinhibition recruited more regular firing neurons for action potential generation during SWRs post-SE. By contrast, burster neurons generated fewer action potential bursts during SWRs post-SE. Furthermore, altered timing of postsynaptic and action potentials suggested distorted neuronal recruitment during SWRs. Distorted subicular SWRs may therefore impair information processing and memory consolidation in epilepsy. |
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| DOI: | doi:10.1016/j.nbd.2022.105929 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.nbd.2022.105929 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0969996122003217 |
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| | DOI: https://doi.org/10.1016/j.nbd.2022.105929 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Burster neurons |
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| | Epilepsy |
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| | Hippocampus |
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| | Memory |
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| | Regular firing neurons |
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| | Sharp wave-ripples |
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| | Status epilepticus |
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| | Subiculum |
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| K10plus-PPN: | 1832748944 |
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| Verknüpfungen: | → Zeitschrift |
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Status epilepticus induces chronic silencing of burster and dominance of regular firing neurons during sharp wave-ripples in the mouse subiculum / Lippmann, Kristina [VerfasserIn]; 24 November 2022 (Online-Ressource)
