Phenotypic and functional analysis of γδ T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection

• Verfasst von: Ruggieri, Matias [VerfasserIn]
• Verfasst von: Ducasa, Nicolás [VerfasserIn]
• Verfasst von: Juraske, Claudia [VerfasserIn]
• Verfasst von: Polo, Virginia Gonzalez [VerfasserIn]
• Verfasst von: Berini, Carolina [VerfasserIn]
• Verfasst von: Quiroga, Maria Florencia [VerfasserIn]
• Verfasst von: Christopoulos, Petros [VerfasserIn]
• Verfasst von: Minguet, Susana [VerfasserIn]
• Verfasst von: Biglione, Mirna [VerfasserIn]
• Verfasst von: Schamel, Wolfgang [VerfasserIn]
• Titel: Phenotypic and functional analysis of γδ T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection
• Verf.angabe: Matias Ruggieri, Nicolás Ducasa, Claudia Juraske, Virginia Gonzalez Polo, Carolina Berini, Maria Florencia Quiroga, Petros Christopoulos, Susana Minguet, Mirna Biglione and Wolfgang W. Schamel
• E-Jahr: 2022
• Jahr: 11 August 2022
• Umfang: 15 S.
• Fussnoten: Gesehen am 31.01.2023
• Titel Quelle: Enthalten in: Frontiers in immunology
• Ort Quelle: Lausanne : Frontiers Media, 2010
• Jahr Quelle: 2022
• Band/Heft Quelle: 13(2022), Artikel-ID 920888, Seite 1-15
• ISSN Quelle: 1664-3224
• DOI: doi:10.3389/fimmu.2022.920888
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1832797708

Abstract

The human T-cell leukemia virus type 1 (HTLV-1) is the cause of serious malignant and inflammatory diseases, including adult T-cell leukemia and lymphoma and tropical spastic paraparesis. The potential protective role of γδ T cells in HTLV-1 infection remains unclear. Here, demonstrate that there is a decrease in the amount of Vγ9Vδ2 T cells in patients with HTLV-1, especially in those with HTLV-1 associated pathologies. This suggests that γδ T cells could be involved in controlling the virus. Indeed, we found that Vγ9Vδ2 T cells, expanded from non-infected individuals, can kill cells expressing the viral proteins HBZ and Tax and this phenotype is reversed in the presence of mevastatin. Cytotoxicity by Vγ9Vδ2 T cells was not associated with an increase of INF-γ production. In sharp contrast, killing by NK cells was reduced by Tax expression. Thus, our study provides initial evidence for a potential protective role of Vγ9Vδ2 T cells against HTLV-1 infection. Therapeutic exploitation of these insights is feasible with current technologies of T-cell therapies and could provide novel tools to prevent and treat HTLV-1-associated malignancies and neurologic complications.