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Verfasst von:Schunk, Stefan [VerfasserIn]   i
 Triem, Sarah [VerfasserIn]   i
 Schmit, David [VerfasserIn]   i
 Zewinger, Stephen [VerfasserIn]   i
 Sarakpi, Tamim [VerfasserIn]   i
 Becker, Ellen [VerfasserIn]   i
 Hütter, Gregor [VerfasserIn]   i
 Wrublewsky, Selina [VerfasserIn]   i
 Küting, Fabienne [VerfasserIn]   i
 Hohl, Mathias [VerfasserIn]   i
 Alansary, Dalia [VerfasserIn]   i
 Prates Roma, Leticia [VerfasserIn]   i
 Lipp, Peter [VerfasserIn]   i
 Möllmann, Julia [VerfasserIn]   i
 Lehrke, Michael [VerfasserIn]   i
 Laschke, Matthias W. [VerfasserIn]   i
 Menger, Michael D. [VerfasserIn]   i
 Kramann, Rafael [VerfasserIn]   i
 Boor, Peter [VerfasserIn]   i
 Jahnen-Dechent, Willi [VerfasserIn]   i
 März, Winfried [VerfasserIn]   i
 Böhm, Michael [VerfasserIn]   i
 Laufs, Ulrich [VerfasserIn]   i
 Niemeyer, Barbara A. [VerfasserIn]   i
 Fliser, Danilo [VerfasserIn]   i
 Ampofo, Emmanuel [VerfasserIn]   i
 Speer, Thimoteus [VerfasserIn]   i
Titel:Interleukin-1α Is a central regulator of leukocyte-endothelial adhesion in myocardial infarction and in chronic kidney disease
Verf.angabe:Stefan J. Schunk, Sarah Triem, David Schmit, Stephen Zewinger, Tamim Sarakpi, Ellen Becker, Gregor Hütter, Selina Wrublewsky, Fabienne Küting, Mathias Hohl, Dalia Alansary, Leticia Prates Roma, Peter Lipp, Julia Möllmann, Michael Lehrke, Matthias W. Laschke, Michael D. Menger, Rafael Kramann, Peter Boor, Willi Jahnen-Dechent, Winfried März, Michael Böhm, Ulrich Laufs, Barbara A. Niemeyer, Danilo Fliser, Emmanuel Ampofo and Thimoteus Speer
E-Jahr:2021
Jahr:14 September 2021
Umfang:16 S.
Fussnoten:Gesehen am 01.02.2023
Titel Quelle:Enthalten in: Circulation
Ort Quelle:Philadelphia, Pa. : Lippincott, Williams & Wilkins, 1950
Jahr Quelle:2021
Band/Heft Quelle:144(2021), 11 vom: Sept., Seite 893-908
ISSN Quelle:1524-4539
Abstract:Background: - - Cardiovascular diseases and chronic kidney disease (CKD) are highly prevalent, aggravate each other, and account for substantial mortality. Both conditions are characterized by activation of the innate immune system. The alarmin interleukin-1α (IL-1α) is expressed in a variety of cell types promoting (sterile) systemic inflammation. The aim of the present study was to examine the role of IL-1α in mediating inflammation in the setting of acute myocardial infarction (AMI) and CKD. - - Methods: - - We assessed the expression of IL-1α on the surface of monocytes from patients with AMI and patients with CKD and determined its association with atherosclerotic cardiovascular disease events during follow-up in an explorative clinical study. Furthermore, we assessed the inflammatory effects of IL-1α in several organ injury models in Il1a−/− and Il1b−/− mice and investigated the underlying mechanisms in vitro in monocytes and endothelial cells. - - Results: - - IL-1α is strongly expressed on the surface of monocytes from patients with AMI and CKD compared with healthy controls. Higher IL-1α surface expression on monocytes from patients with AMI and CKD was associated with a higher risk for atherosclerotic cardiovascular disease events, which underlines the clinical relevance of IL-1α. In mice, IL-1α, but not IL-1β, mediates leukocyte-endothelial adhesion as determined by intravital microscopy. IL-1α promotes accumulation of macrophages and neutrophils in inflamed tissue in vivo. Furthermore, IL-1α on monocytes stimulates their homing at sites of vascular injury. A variety of stimuli such as free fatty acids or oxalate crystals induce IL-1α surface expression and release by monocytes, which then mediates their adhesion to the endothelium via IL-1 receptor-1. IL-1α also promotes expression of the VCAM-1 (vascular cell adhesion molecule-1) on endothelial cells, thereby fostering the adhesion of circulating leukocytes. IL-1α induces inflammatory injury after experimental AMI, and abrogation of IL-1α prevents the development of CKD in oxalate or adenine-fed mice. - - Conclusions: - - IL-1α represents a key mediator of leukocyte-endothelial adhesion and inflammation in AMI and CKD. Inhibition of IL-1α may serve as a novel anti-inflammatory treatment strategy.
DOI:doi:10.1161/CIRCULATIONAHA.121.053547
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1161/CIRCULATIONAHA.121.053547
 Volltext: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.053547
 DOI: https://doi.org/10.1161/CIRCULATIONAHA.121.053547
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chronic kidney disease
 inflammation
 interleukin-1α
 leukocyte adhesion
 myocardial infarction
K10plus-PPN:1832916316
Verknüpfungen:→ Zeitschrift

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