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| Verfasst von: | Bockmayr, Michael [VerfasserIn]  |
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| | Harnisch, Kim [VerfasserIn] |
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| | Pohl, Lara C [VerfasserIn] |
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| | Schweizer, Leonille [VerfasserIn] |
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| | Mohme, Theresa [VerfasserIn] |
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| | Körner, Meik [VerfasserIn] |
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| | Alawi, Malik [VerfasserIn] |
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| | Suwala, Abigail Kora [VerfasserIn] |
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| | Dorostkar, Mario M [VerfasserIn] |
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| | Monoranu, Camelia M [VerfasserIn] |
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| | Hasselblatt, Martin [VerfasserIn] |
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| | Wefers, Annika K [VerfasserIn] |
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| | Capper, David [VerfasserIn] |
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| | Hench, Jürgen [VerfasserIn] |
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| | Frank, Stephan [VerfasserIn] |
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| | Richardson, Timothy E [VerfasserIn] |
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| | Tran, Ivy [VerfasserIn] |
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| | Liu, Elisa [VerfasserIn] |
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| | Snuderl, Matija [VerfasserIn] |
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| | Engertsberger, Lara [VerfasserIn] |
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| | Benesch, Martin [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Obrecht, Denise [VerfasserIn] |
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| | Mynarek, Martin [VerfasserIn] |
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| | Rutkowski, Stefan [VerfasserIn] |
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| | Glatzel, Markus [VerfasserIn] |
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| | Neumann, Julia E [VerfasserIn] |
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| | Schüller, Ulrich [VerfasserIn] |
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| Titel: | Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease |
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| Verf.angabe: | Michael Bockmayr, Kim Harnisch, Lara C Pohl, Leonille Schweizer, Theresa Mohme, Meik Körner, Malik Alawi, Abigail K Suwala, Mario M Dorostkar, Camelia M Monoranu, Martin Hasselblatt, Annika K Wefers, David Capper, Jürgen Hench, Stephan Frank, Timothy E Richardson, Ivy Tran, Elisa Liu, Matija Snuderl, Lara Engertsberger, Martin Benesch, Andreas von Deimling, Denise Obrecht, Martin Mynarek, Stefan Rutkowski, Markus Glatzel, Julia E Neumann, and Ulrich Schüller |
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| E-Jahr: | 2022 |
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| Jahr: | [October 2022] |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Published: 05 April 2022 ; Gesehen am 01.02.2023 |
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| Titel Quelle: | Enthalten in: Neuro-Oncology |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1999 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 24(2022), 10 vom: Okt., Seite 1689-1699 |
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| ISSN Quelle: | 1523-5866 |
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| Abstract: | Myxopapillary ependymoma (MPE) is a heterogeneous disease regarding histopathology and outcome. The underlying molecular biology is poorly understood, and markers that reliably predict the patients’ clinical course are unknown.We assembled a cohort of 185 tumors classified as MPE based on DNA methylation. Methylation patterns, copy number profiles, and MGMT promoter methylation were analyzed for all tumors, 106 tumors were evaluated histomorphologically, and RNA sequencing was performed for 37 cases. Based on methylation profiling, we defined two subtypes MPE-A and MPE-B, and explored associations with epidemiological, clinical, pathological, and molecular characteristics of these tumors.MPE-A occurred at a median age of 27 years and were enriched with tumors demonstrating papillary morphology and MGMT promoter hypermethylation. Half of these tumors could not be totally resected, and 85% relapsed within 10 years. Copy number alterations were more common in MPE-A. RNA sequencing revealed an enrichment for extracellular matrix and immune system-related signatures in MPE-A. MPE-B occurred at a median age of 45 years and included many tumors with a histological diagnosis of WHO grade II and tanycytic morphology. Patients within this subtype had a significantly better outcome with a relapse rate of 33% in 10 years (P = 3.4e-06).We unraveled the morphological and clinical heterogeneity of MPE by identifying two molecularly distinct subtypes. These subtypes significantly differed in progression-free survival and will likely need different protocols for surveillance and treatment. |
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| DOI: | doi:10.1093/neuonc/noac088 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/neuonc/noac088 |
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| | DOI: https://doi.org/10.1093/neuonc/noac088 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1832958450 |
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| Verknüpfungen: | → Zeitschrift |
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Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease / Bockmayr, Michael [VerfasserIn]; [October 2022] (Online-Ressource)
