Uremia aggravates left ventricular remodeling after myocardial infarction

• Verfasst von: Dikow, Ralf [VerfasserIn]
• Verfasst von: Schmidt, Ulrike Stefanie [VerfasserIn]
• Verfasst von: Kihm, Lars Philipp [VerfasserIn]
• Verfasst von: Schaier, Matthias [VerfasserIn]
• Verfasst von: Schwenger, Vedat [VerfasserIn]
• Verfasst von: Groß-Weissmann, Marie-Luise [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Zeier, Martin [VerfasserIn]
• Verfasst von: Hardt, Stefan [VerfasserIn]
• Titel: Uremia aggravates left ventricular remodeling after myocardial infarction
• Verf.angabe: Ralf Dikow, Ulrike Schmidt, Lars P. Kihm, Matthias Schaier, Vedat Schwenger, Marie-Luise Gross, Hugo A. Katus, Martin Zeier, Stefan E. Hardt
• E-Jahr: 2010
• Jahr: May 19, 2010
• Umfang: 10 S.
• Fussnoten: Gesehen am 02.02.2023
• Titel Quelle: Enthalten in: American journal of nephrology
• Ort Quelle: Basel [u.a.] : Karger, 1981
• Jahr Quelle: 2010
• Band/Heft Quelle: 32(2010), 1, Seite 13-22
• ISSN Quelle: 1421-9670
• DOI: doi:10.1159/000313846
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1833079167

Abstract

Background: Renal failure is a well-established cardiovascular risk factor. We hypothesized that uremia negatively affects post-myocardial infarction (MI) remodeling and left ventricular (LV) function and examined the pathohistological correlations. Methods: Subtotally nephrectomized rats (SNX) and controls with MI only (MIC) were examined 1, 4 and 8 weeks after MI. MI size, ejection fraction (EF), cardiac fibrosis, vascular density and cardiomyocyte density were studied. Results: The extension of MI was 0.08 ± 0.02 in SNX versus 0.06 ± 0.02 in MIC rats (p < 0.031). Prior to MI, EF was comparable in SNX and MIC (74 ± 3 vs. 72 ± 2%, n.s.). Despite a relatively small infarct size EF in SNX decreased to 58 ± 4% 1 week after infarction and progressively worsened to 51 ± 4% after 8 weeks. In MIC animals EF only slightly decreased 1 week after MI (70 ± 3%) and remained unchanged at follow-up. In SNX animals LV end-diastolic diameter continuously increased following MI throughout the study period indicating accelerated remodeling. Furthermore, accelerated myocardial fibrosis was already notable 1 week after MI in SNX animals and the volume density of capillaries and cardiomyocytes was significantly lower in SNX rats. Conclusion: MI in experimental uremia is associated with progressive impairment of LV function, LV dilatation and accelerated myocardial fibrosis.