Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Schupp, Tobias [VerfasserIn]   i
 Weidner, Kathrin [VerfasserIn]   i
 Rusnak, Jonas [VerfasserIn]   i
 Jawhar, Schanas [VerfasserIn]   i
 Forner, Jan [VerfasserIn]   i
 Dulatahu, Floriana [VerfasserIn]   i
 Brück, Lea Marie [VerfasserIn]   i
 Hoffmann, Ursula [VerfasserIn]   i
 Kittel, Maximilian [VerfasserIn]   i
 Bertsch, Thomas [VerfasserIn]   i
 Akın, Ibrahim [VerfasserIn]   i
 Behnes, Michael [VerfasserIn]   i
Titel:Diagnostic and prognostic role of platelets in patients with sepsis and septic shock
Verf.angabe:Tobias Schupp, Kathrin Weidner, Jonas Rusnak, Schanas Jawhar, Jan Forner, Floriana Dulatahu, Lea Marie Brück, Ursula Hoffmann, Maximilian Kittel, Thomas Bertsch, Ibrahim Akin, & Michael Behnes
Jahr:2023
Umfang:13 S.
Fussnoten:Published online: 09 Dec 2022 ; Gesehen am 06.02.2023
Titel Quelle:Enthalten in: Platelets
Ort Quelle:London : Taylor & Francis, 1990
Jahr Quelle:2023
Band/Heft Quelle:34(2023), 1, Artikel-ID 2131753, Seite 1-13
ISSN Quelle:1369-1635
Abstract:Studies investigating the prognostic role of platelets commonly include critically ill patients, whereas data regarding the prognostic impact of platelet count in patients admitted with sepsis and septic shock is limited. Therefore, the study investigates the prognostic role of platelet count in patients with sepsis and septic shock. Consecutive patients with sepsis and septic shock from 2019 to 2021 were included monocentrically. Blood samples were retrieved from the day of disease onset (day 1), days 2, 3, 5, 7 and 10. Firstly, the diagnostic value of platelet count was tested for septic shock compared to sepsis. Secondly, the prognostic value of platelet count was tested for 30-day all-cause mortality. Statistical analyses included univariable t-test, Spearman’s correlation, C-statistics, Kaplan-Meier analyses, as well as multivariable mixed analysis of variance (ANOVA), Cox proportional regression analyses and propensity score matching. A total of 358 patients with sepsis and septic shock were included with a median platelet count of 176 × 106/ml. The presence of thrombocytopenia (i.e. <150 × 106/ml) was associated with increased risk of 30-day mortality (HR = 1.409; 95% CI 1.057-1.878; p = .019), which was still demonstrated after propensity score matching. During the course of sepsis, a nadir was observed on sepsis day 5 with a decrease in the mean platelet count by 21.5%. Especially serum lactate, mean arterial pressure and the presence of malignancies were found to predict platelet decline during the course of sepsis/septic shock. The presence of platelet decline >25% was associated with an increased risk of 30-day all-cause mortality (HR = 1.484; 95% CI 1.045-2.109; p = .028). Following platelet decline, recovery was observed from day 5 to day 10 (mean increase 7.5%). However, platelet recovery was not found to be associated with 30-day all-cause mortality (HR = 1.072; 95% CI 0.567-2.026; p = .832). In conclusion, both thrombocytopenia and platelet decline during the course of sepsis were associated with an increased risk of 30-day all-mortality in patients admitted with sepsis or septic shock.
DOI:doi:10.1080/09537104.2022.2131753
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1080/09537104.2022.2131753
 DOI: https://doi.org/10.1080/09537104.2022.2131753
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Mortality
 platelet count
 prognosis
 sepsis
 septic shock
 thrombocytopenia
K10plus-PPN:1833248848
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69037938   QR-Code
zum Seitenanfang