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Verfasst von:Distler, Oliver [VerfasserIn]   i
 Eich, Wolfgang [VerfasserIn]   i
 Dokoupilova, Eva [VerfasserIn]   i
 Dvorak, Zdenek [VerfasserIn]   i
 Fleck, Martin [VerfasserIn]   i
 Gaubitz, Markus [VerfasserIn]   i
 Hechler, Manfred [VerfasserIn]   i
 Jansen, Jan-Peter [VerfasserIn]   i
 Krause, Andreas [VerfasserIn]   i
 Bendszus, Martin [VerfasserIn]   i
 Pache, Lothar [VerfasserIn]   i
 Reiter, Rudolf [VerfasserIn]   i
 Müller-Ladner, Ulf [VerfasserIn]   i
Titel:Evaluation of the efficacy and safety of terguride in patients with fibromyalgia syndrome
Titelzusatz:results of a twelve-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Verf.angabe:Oliver Distler, Wolfgang Eich, Eva Dokoupilova, Zdenek Dvorak, Martin Fleck, Markus Gaubitz, Manfred Hechler, Jan-Peter Jansen, Andreas Krause, Martin Bendszus, Lothar Pache, Rudolf Reiter, and Ulf Müller-Ladner
Jahr:2010
Umfang:10 S.
Fussnoten:Online: 28 December 2009 ; Gesehen am 06.02.2023
Titel Quelle:Enthalten in: Arthritis & rheumatism
Ort Quelle:Hoboken, NJ : Wiley-Blackwell, 1958
Jahr Quelle:2010
Band/Heft Quelle:62(2010), 1 vom: Jan., Seite 291-300
ISSN Quelle:1529-0131
Abstract:Objective: To assess the efficacy and safety of terguride, a partial dopamine agonist, in patients with fibromyalgia syndrome (FMS). Methods: In a 12-week, multicenter, double-blind, placebo-controlled, parallel-group study, 99 patients were randomized at a ratio of 2 to 1 to receive terguride or placebo. Over 21 days, the dosage was titrated to a maximum daily dose of 3 mg of terguride or placebo, and this fixed dosage was continued over 9 weeks. The primary efficacy variable was the intensity of pain (100-mm visual analog scale). Secondary efficacy variables included the Fibromyalgia Impact Questionnaire (FIQ) score, the tender point score (TPS), and the Hamilton Depression Scale (HDS) score. During the study, patients were evaluated for the presence of cervical spine stenosis by magnetic resonance imaging (MRI). Results: No significant differences in the change in pain intensity, FIQ score, TPS, or HDS score between baseline and 12 weeks were observed in the terguride group as compared with the placebo group. Cervical spine stenosis was detected in 22% of the patients. Only patients with cervical spine stenosis responded to terguride treatment. FIQ scores improved significantly (per-protocol analysis), and pain intensity, the TPS score, and the HDS score showed a trend toward improvement in the terguride group as compared with the placebo group. Terguride treatment was safe. Only those adverse events already known to be side effects of terguride were observed. Premature termination of the study in patients receiving terguride (26%) occurred predominantly during up-titration and in the absence of comedication for treatment of nausea. Conclusion: Terguride treatment did not improve pain, the FIQ score, the TPS, or the HDS score in the total study population. However, a subgroup of patients with cervical spine stenosis seemed to benefit from terguride treatment.
DOI:doi:10.1002/art.25062
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/art.25062
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/art.25062
 DOI: https://doi.org/10.1002/art.25062
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1833266625
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