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Verfasst von:Meixner, Eva [VerfasserIn]   i
 Arians, Nathalie [VerfasserIn]   i
 Bougatf, Nina [VerfasserIn]   i
 Hoeltgen, Line [VerfasserIn]   i
 König, Laila [VerfasserIn]   i
 Lang, Kristin [VerfasserIn]   i
 Domschke, Christoph [VerfasserIn]   i
 Wallwiener, Markus [VerfasserIn]   i
 Lischalk, Jonathan W. [VerfasserIn]   i
 Kommoss, Felix [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Hörner-Rieber, Juliane [VerfasserIn]   i
Titel:Vaginal cancer treated with curative radiotherapy with or without concomitant chemotherapy
Titelzusatz:oncologic outcomes and prognostic factors
Verf.angabe:Eva Meixner, Nathalie Arians, Nina Bougatf, Line Hoeltgen, Laila König, Kristin Lang, Christoph Domschke, Markus Wallwiener, Jonathan W. Lischalk, Felix K.F. Kommoss, Jürgen Debus and Juliane Hörner-Rieber
Jahr:2023
Umfang:9 S.
Fussnoten:First published online November 1, 2021 ; Gesehen am 06.02.2023
Titel Quelle:Enthalten in: Tumori journal
Ort Quelle:Thousand Oaks, Calif. : Sage Publishing, 1947
Jahr Quelle:2023
Band/Heft Quelle:109(2023), 1, Seite 112-120
ISSN Quelle:2038-2529
Abstract:Background:Vaginal cancer is a rare disease for which prospective randomized trials do not exist. We aimed to assess survival outcomes, patterns of recurrence, prognostic factors, and toxicity in the curative treatment using image-guided radiotherapy (RT).Methods:In this retrospective review, we identified 53 patients who were treated at a single center with external beam radiotherapy and brachytherapy with or without concomitant chemotherapy from 2000 to 2021.Results:With a median follow-up of 64.5 months, the Kaplan-Meier 2-, 5-, and 7-year overall survival (OS) was found to be 74.8%, 62.8%, and 58.9%, respectively. Local and distant control were 67.8%, 65.0%, and 65.0% and 74.4%, 62.6%, and 62.6% at 2, 5, and 7 years, respectively. In univariate Cox proportional hazards ratio analysis, OS was significantly correlated to FIGO stage (hazard ratio [HR] 1.78, p = 0.042), postoperative RT (HR 0.41, p = 0.044), and concomitant chemotherapy (HR 0.31, p = 0.009). Local control rates were superior when an equivalent dose in 2-Gy fractions (EQD2) of ?65 Gy was delivered (HR 0.216, p = 0.028) and with the use of concurrent chemotherapy (HR 0.248, p = 0.011). Not surprisingly, local control was inferior for patients with a higher TNM stage (HR 3.303, p = 0.027). Minimal toxicity was observed with no patients having documentation of high-grade toxicity (CTCAE grade 3+).Conclusion:In treatment of vaginal cancer, high-dose RT in combination with brachytherapy is well tolerated and results in effective local control rates, which significantly improve with an EQD2(α/?=10) ?65 Gy. Multivariate analyses revealed concomitant chemotherapy was a positive prognostic factor for overall and progression-free survival.
DOI:doi:10.1177/03008916211056369
URL:kostenfrei: Volltext: https://doi.org/10.1177/03008916211056369
 kostenfrei: Volltext: https://journals.sagepub.com/doi/10.1177/03008916211056369
 DOI: https://doi.org/10.1177/03008916211056369
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1833331478
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