| Online-Ressource |
Verfasst von: | Meixner, Eva [VerfasserIn]  |
| Arians, Nathalie [VerfasserIn]  |
| Bougatf, Nina [VerfasserIn]  |
| Hoeltgen, Line [VerfasserIn]  |
| König, Laila [VerfasserIn]  |
| Lang, Kristin [VerfasserIn]  |
| Domschke, Christoph [VerfasserIn]  |
| Wallwiener, Markus [VerfasserIn]  |
| Lischalk, Jonathan W. [VerfasserIn]  |
| Kommoss, Felix [VerfasserIn]  |
| Debus, Jürgen [VerfasserIn]  |
| Hörner-Rieber, Juliane [VerfasserIn]  |
Titel: | Vaginal cancer treated with curative radiotherapy with or without concomitant chemotherapy |
Titelzusatz: | oncologic outcomes and prognostic factors |
Verf.angabe: | Eva Meixner, Nathalie Arians, Nina Bougatf, Line Hoeltgen, Laila König, Kristin Lang, Christoph Domschke, Markus Wallwiener, Jonathan W. Lischalk, Felix K.F. Kommoss, Jürgen Debus and Juliane Hörner-Rieber |
Jahr: | 2023 |
Umfang: | 9 S. |
Fussnoten: | First published online November 1, 2021 ; Gesehen am 06.02.2023 |
Titel Quelle: | Enthalten in: Tumori journal |
Ort Quelle: | Thousand Oaks, Calif. : Sage Publishing, 1947 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 109(2023), 1, Seite 112-120 |
ISSN Quelle: | 2038-2529 |
Abstract: | Background:Vaginal cancer is a rare disease for which prospective randomized trials do not exist. We aimed to assess survival outcomes, patterns of recurrence, prognostic factors, and toxicity in the curative treatment using image-guided radiotherapy (RT).Methods:In this retrospective review, we identified 53 patients who were treated at a single center with external beam radiotherapy and brachytherapy with or without concomitant chemotherapy from 2000 to 2021.Results:With a median follow-up of 64.5 months, the Kaplan-Meier 2-, 5-, and 7-year overall survival (OS) was found to be 74.8%, 62.8%, and 58.9%, respectively. Local and distant control were 67.8%, 65.0%, and 65.0% and 74.4%, 62.6%, and 62.6% at 2, 5, and 7 years, respectively. In univariate Cox proportional hazards ratio analysis, OS was significantly correlated to FIGO stage (hazard ratio [HR] 1.78, p = 0.042), postoperative RT (HR 0.41, p = 0.044), and concomitant chemotherapy (HR 0.31, p = 0.009). Local control rates were superior when an equivalent dose in 2-Gy fractions (EQD2) of ?65 Gy was delivered (HR 0.216, p = 0.028) and with the use of concurrent chemotherapy (HR 0.248, p = 0.011). Not surprisingly, local control was inferior for patients with a higher TNM stage (HR 3.303, p = 0.027). Minimal toxicity was observed with no patients having documentation of high-grade toxicity (CTCAE grade 3+).Conclusion:In treatment of vaginal cancer, high-dose RT in combination with brachytherapy is well tolerated and results in effective local control rates, which significantly improve with an EQD2(α/?=10) ?65 Gy. Multivariate analyses revealed concomitant chemotherapy was a positive prognostic factor for overall and progression-free survival. |
DOI: | doi:10.1177/03008916211056369 |
URL: | kostenfrei: Volltext: https://doi.org/10.1177/03008916211056369 |
| kostenfrei: Volltext: https://journals.sagepub.com/doi/10.1177/03008916211056369 |
| DOI: https://doi.org/10.1177/03008916211056369 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1833331478 |
Verknüpfungen: | → Zeitschrift |
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Lokale URL UB: | Zum Volltext |
Vaginal cancer treated with curative radiotherapy with or without concomitant chemotherapy / Meixner, Eva [VerfasserIn]; 2023 (Online-Ressource)