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Verfasst von:Dösch, Andreas [VerfasserIn]   i
 Müller, Susanne [VerfasserIn]   i
 Konstandin, Mathias [VerfasserIn]   i
 Celik, Sultan [VerfasserIn]   i
 Kristen, Arnt [VerfasserIn]   i
 Frankenstein, Lutz [VerfasserIn]   i
 Göser, Stefan [VerfasserIn]   i
 Kaya, Ziya [VerfasserIn]   i
 Zugck, Christian [VerfasserIn]   i
 Dengler, Thomas [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
Titel:Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathy
Verf.angabe:Andreas O. Doesch, Susanne Mueller, Mathias Konstandin, Sultan Celik, Arnt Kristen, Lutz Frankenstein, Stefan Goeser, Ziya Kaya, Christian Zugck, Thomas J. Dengler, and Hugo A. Katus
E-Jahr:2010
Jahr:7 September 2010
Umfang:8 S.
Fussnoten:Gesehen am 13.02.2023
Titel Quelle:Enthalten in: Journal of clinical apheresis
Ort Quelle:New York, NY : Wiley Interscience, 1983
Jahr Quelle:2010
Band/Heft Quelle:25(2010), 6, Seite 315-322
ISSN Quelle:1098-1101
Abstract:Objectives: The objective of this study was to investigate functional effects of immunoadsorption (IA) in patients with chronic nonfamilial dilated cardiomyopathy (DCM) regarding clinical and humoral markers of heart failure. Background: IA has been shown to induce early hemodynamic improvement in patients with nonfamilial dilated cardiomyopathy (DCM). Methods: We performed IA using protein A agarose columns on five consecutive days in 51 patients with chronic DCM, congestive heart failure of NYHA class ≥ II, left ventricular ejection fraction ≤50%, and mean time since initial diagnosis of 5.0 ± 5.8 years. Results: Immediately after IA, immunoglobulin G (IgG) decreased by 89.4% and IgG3 by 66.7% (both P < 0.0001). Median NT-pro BNP was reduced from 1230.0 ng L−1 at baseline to 829.0 ng L−1 after 6 months (P < 0.0001). Also mean left ventricular ejection fraction (LVEF) was significantly improved (26.3% ± 9.4% to 28.7% ± 11.4% after 6 months, P = 0.016) and LVEF improved ≥5% (absolute) in 21 of 51 (41.2%) patients. After 6 months, bicycle spiroergometry showed a significant increase in exercise capacity from 82.0 ± 30.8 Watts to 93.1 ± 34.3 Watts (P = 0.008) while VO2max rose from 15.0 ± 4.1 to 16.4 ± 4.8 mL min−1 kg−1 (P = 0.01). Conclusions: In this study, on heart failure patients with nonfamilial DCM, IA therapy significantly improved clinical and humoral markers of heart failure severity. These promising results may be due to the selected study population, with a shorter disease duration and the higher amount of IgG 3 reduction. Future blinded prospective multicenter studies are necessary to identify those patients that benefit most.
DOI:doi:10.1002/jca.20263
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/jca.20263
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.20263
 DOI: https://doi.org/10.1002/jca.20263
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:clinical effects
 dilated cardiomyopathy
 protein A immunoadsorption
K10plus-PPN:1834614694
Verknüpfungen:→ Zeitschrift

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