| |  Online-Ressource |
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| Verfasst von: | Reinwald, Jonathan Rochus [VerfasserIn]  |
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| | Weber-Fahr, Wolfgang [VerfasserIn] |
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| | Cosa‐Linan, Alejandro [VerfasserIn] |
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| | Becker, Robert [VerfasserIn] |
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| | Sack, Markus [VerfasserIn] |
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| | Falfán‐Melgoza, Claudia [VerfasserIn] |
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| | Gass, Natalia [VerfasserIn] |
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| | Braun, Urs [VerfasserIn] |
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| | Clemm von Hohenberg, Christian [VerfasserIn] |
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| | Chen, Jiesi [VerfasserIn] |
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| | Mayerl, Steffen [VerfasserIn] |
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| | Münte, Thomas Frank [VerfasserIn] |
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| | Heuer, Heike [VerfasserIn] |
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| | Sartorius, Alexander [VerfasserIn] |
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| Titel: | TRIAC treatment improves impaired brain network function and white matter loss in thyroid hormone transporter Mct8/Oatp1c1 deficient mice |
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| Verf.angabe: | Jonathan Rochus Reinwald, Wolfgang Weber-Fahr, Alejandro Cosa-Linan, Robert Becker, Markus Sack, Claudia Falfan-Melgoza, Natalia Gass, Urs Braun, Christian Clemm von Hohenberg, Jiesi Chen, Steffen Mayerl, Thomas F. Muente, Heike Heuer and Alexander Sartorius |
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| E-Jahr: | 2022 |
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| Jahr: | 8 December 2022 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 14.02.2023 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 23(2022), 24, Artikel-ID 15547, Seite 1-19 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Dysfunctions of the thyroid hormone (TH) transporting monocarboxylate transporter MCT8 lead to a complex X-linked syndrome with abnormal serum TH concentrations and prominent neuropsychiatric symptoms (Allan-Herndon-Dudley syndrome, AHDS). The key features of AHDS are replicated in double knockout mice lacking MCT8 and organic anion transporting protein OATP1C1 (Mct8/Oatp1c1 DKO). In this study, we characterize impairments of brain structure and function in Mct8/Oatp1c1 DKO mice using multimodal magnetic resonance imaging (MRI) and assess the potential of the TH analogue 3,3′,5-triiodothyroacetic acid (TRIAC) to rescue this phenotype. Structural and functional MRI were performed in 11-weeks-old male Mct8/Oatp1c1 DKO mice (N = 10), wild type controls (N = 7) and Mct8/Oatp1c1 DKO mice (N = 13) that were injected with TRIAC (400 ng/g bw s.c.) daily during the first three postnatal weeks. Grey and white matter volume were broadly reduced in Mct8/Oatp1c1 DKO mice. TRIAC treatment could significantly improve white matter thinning but did not affect grey matter loss. Network-based statistic showed a wide-spread increase of functional connectivity, while graph analysis revealed an impairment of small-worldness and whole-brain segregation in Mct8/Oatp1c1 DKO mice. Both functional deficits could be substantially ameliorated by TRIAC treatment. Our study demonstrates prominent structural and functional brain alterations in Mct8/Oatp1c1 DKO mice that may underlie the psychomotor deficiencies in AHDS. Additionally, we provide preclinical evidence that early-life TRIAC treatment improves white matter loss and brain network dysfunctions associated with TH transporter deficiency. |
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| DOI: | doi:10.3390/ijms232415547 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms232415547 |
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| | Volltext: https://www.mdpi.com/1422-0067/23/24/15547 |
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| | DOI: https://doi.org/10.3390/ijms232415547 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Allan-Herndon-Dudley-syndrome |
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| | brain network |
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| | graph analysis |
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| | Slc16a2 |
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| | Slco1c1 |
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| | T3 |
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| | T4 |
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| | thyroid hormone |
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| | voxel-based morphometry |
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| K10plus-PPN: | 1835067492 |
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| Verknüpfungen: | → Zeitschrift |
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TRIAC treatment improves impaired brain network function and white matter loss in thyroid hormone transporter Mct8/Oatp1c1 deficient mice / Reinwald, Jonathan Rochus [VerfasserIn]; 8 December 2022 (Online-Ressource)
