A model guided approach to evoke homogeneous behavior during temporal reward and loss discounting

• Verfasst von: Thome, Janine [VerfasserIn]
• Verfasst von: Pinger, Mathieu [VerfasserIn]
• Verfasst von: Halli, Patrick [VerfasserIn]
• Verfasst von: Durstewitz, Daniel [VerfasserIn]
• Verfasst von: Sommer, Wolfgang H. [VerfasserIn]
• Verfasst von: Kirsch, Peter [VerfasserIn]
• Verfasst von: Koppe, Georgia [VerfasserIn]
• Titel: A model guided approach to evoke homogeneous behavior during temporal reward and loss discounting
• Verf.angabe: Janine Thome, Mathieu Pinger, Patrick Halli, Daniel Durstewitz, Wolfgang H. Sommer, Peter Kirsch and Georgia Koppe
• E-Jahr: 2022
• Jahr: 21 June 2022
• Umfang: 18 S.
• Fussnoten: Gesehen am 16.02.2023
• Titel Quelle: Enthalten in: Frontiers in psychiatry
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2022
• Band/Heft Quelle: 13(2022), Artikel-ID 846119, Seite 1-18
• ISSN Quelle: 1664-0640
• DOI: doi:10.3389/fpsyt.2022.846119
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1836318227

Abstract

BackgroundThe tendency to devaluate future options as a function of time, known as delay discounting, is associated with various factors such as psychiatric illness and personality. Under identical experimental conditions, individuals may therefore strongly differ in the degree to which they discount future options. In delay discounting tasks, this inter-individual variability inevitably results in an unequal number of discounted trials per subject, generating difficulties in linking delay discounting to psychophysiological and neural correlates. Many studies have therefore focused on assessing delay discounting adaptively. Here, we extend these approaches by developing an adaptive paradigm which aims at inducing more comparable and homogeneous discounting frequencies across participants on a dimensional scale.MethodThe proposed approach probabilistically links a (common) discounting function to behavior to obtain a probabilistic model, and then exploits the model to obtain a formal condition which defines how to construe experimental trials so as to induce any desired discounting probability. We first infer subject-level models on behavior on a non-adaptive delay discounting task and then use these models to generate adaptive trials designed to evoke graded relative discounting frequencies of 0.3, 0.5, and 0.7 in each participant. We further compare and evaluate common models in the field through out-of-sample prediction error estimates, to iteratively improve the trial-generating model and paradigm.ResultsThe developed paradigm successfully increases discounting behavior during both reward and loss discounting. Moreover, it evokes graded relative choice frequencies in line with model-based expectations (i.e., 0.3, 0.5, and 0.7) suggesting that we can successfully homogenize behavior. Our model comparison analyses indicate that hyperboloid models are superior in predicting unseen discounting behavior to more conventional hyperbolic and exponential models. We report out-of-sample error estimates as well as commonalities and differences between reward and loss discounting, demonstrating for instance lower discounting rates, as well as differences in delay perception in loss discounting.ConclusionThe present work proposes a model-based framework to evoke graded responses linked to cognitive function at a single subject level. Such a framework may be used in the future to measure cognitive functions on a dimensional rather than dichotomous scale.