| |  Online-Ressource |
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| Verfasst von: | Domschke, Christoph [VerfasserIn]  |
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| | Schütz, Florian [VerfasserIn] |
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| | Sommerfeldt, Nora [VerfasserIn] |
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| | Rom, Joachim [VerfasserIn] |
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| | Scharf, Alexander [VerfasserIn] |
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| | Sohn, Christof [VerfasserIn] |
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| | Schneeweiss, Andreas [VerfasserIn] |
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| | Beckhove, Philipp [VerfasserIn] |
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| Titel: | Effects of distant metastasis and peripheral CA 15-3 on the induction of spontaneous T cell responses in breast cancer patients |
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| Verf.angabe: | Christoph Domschke, Florian Schuetz, Nora Sommerfeldt, Joachim Rom, Alexander Scharf, Christof Sohn, Andreas Schneeweiss, Philipp Beckhove |
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| Jahr: | 2010 |
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| Umfang: | 8 S. |
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| Fussnoten: | Published online: 2 December 2009 ; Gesehen am 16.02.2023 |
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| Titel Quelle: | Enthalten in: Cancer immunology immunotherapy |
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| Ort Quelle: | Berlin : Springer, 1976 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 59(2010), 3, Seite 479-486 |
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| ISSN Quelle: | 1432-0851 |
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| Abstract: | Tumor-specific memory T cells are detectable in the bone marrow (BM) of a majority of breast cancer patients. In vitro they can be reactivated to IFN-γ producing, cytotoxic effector cells and reject autologous, xenotransplanted tumors in NOD/SCID mice after specific restimulation with autologous dendritic cells (DC). In this study, we demonstrate the presence of specific tumor-reactive BM memory T cells in altogether 56 out of 129 primarily operated breast cancer patients by short-term IFN-γ EliSpot assays with unstimulated T cells and tumor antigen presenting, autologous DCs. We observed tumor-reactive BM memory T cells predominantly in patients with primarily metastatic disease (P = 0.011) or with increased concentrations of tumor marker CA 15-3 in the peripheral blood (P = 0.004), respectively. Memory T cell reactivity against HLA-A*0201-restricted peptides from the tumor-associated antigens MUC1, Hpa16-24 and Hpa183-191 was also detected particularly in patients with elevated peripheral CA 15-3 concentrations (P < 0.05). Altogether these data indicate that the systemic presence of tumor-derived antigens promotes an induction of tumor-specific cellular immune responses in the human BM. |
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| DOI: | doi:10.1007/s00262-009-0801-9 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00262-009-0801-9 |
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| | DOI: https://doi.org/10.1007/s00262-009-0801-9 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bone marrow |
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| | Breast cancer |
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| | Mucin-1 |
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| | T cell immunity |
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| | Tumor antigen |
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| K10plus-PPN: | 1836319185 |
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| Verknüpfungen: | → Zeitschrift |
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Effects of distant metastasis and peripheral CA 15-3 on the induction of spontaneous T cell responses in breast cancer patients / Domschke, Christoph [VerfasserIn]; 2010 (Online-Ressource)
