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| Verfasst von: | Bartl, Jasmin [VerfasserIn]  |
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| | Zanini, Marco [VerfasserIn] |
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| | Bernardi, Flavia [VerfasserIn] |
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| | Forget, Antoine [VerfasserIn] |
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| | Blümel, Lena [VerfasserIn] |
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| | Talbot, Julie [VerfasserIn] |
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| | Picard, Daniel [VerfasserIn] |
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| | Qin, Nan [VerfasserIn] |
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| | Cancila, Gabriele [VerfasserIn] |
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| | Gao, Qingsong [VerfasserIn] |
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| | Nath, Soumav [VerfasserIn] |
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| | Koumba, Idriss Mahoungou [VerfasserIn] |
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| | Wolter, Marietta [VerfasserIn] |
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| | Kuonen, François [VerfasserIn] |
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| | Langini, Maike [VerfasserIn] |
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| | Beez, Thomas [VerfasserIn] |
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| | Munoz, Christopher [VerfasserIn] |
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| | Pauck, David [VerfasserIn] |
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| | Marquardt, Viktoria [VerfasserIn] |
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| | Yu, Hua [VerfasserIn] |
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| | Souphron, Judith [VerfasserIn] |
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| | Korsch, Mascha [VerfasserIn] |
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| | Mölders, Christina [VerfasserIn] |
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| | Berger, Daniel [VerfasserIn] |
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| | Göbbels, Sarah [VerfasserIn] |
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| | Meyer, Frauke-Dorothee [VerfasserIn] |
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| | Scheffler, Björn [VerfasserIn] |
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| | Rotblat, Barak [VerfasserIn] |
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| | Diederichs, Sven [VerfasserIn] |
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| | Ramaswamy, Vijay [VerfasserIn] |
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| | Suzuki, Hiromishi [VerfasserIn] |
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| | Oro, Anthony [VerfasserIn] |
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| | Stühler, Kai [VerfasserIn] |
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| | Stefanski, Anja [VerfasserIn] |
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| | Fischer, Ute [VerfasserIn] |
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| | Leprivier, Gabriel [VerfasserIn] |
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| | Willbold, Dieter [VerfasserIn] |
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| | Steger, Gerhard [VerfasserIn] |
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| | Buell, Alexander [VerfasserIn] |
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| | Kool, Marcel [VerfasserIn] |
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| | Lichter, Peter [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Northcott, Paul A. [VerfasserIn] |
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| | Taylor, Michael D. [VerfasserIn] |
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| | Borkhardt, Arndt [VerfasserIn] |
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| | Reifenberger, Guido [VerfasserIn] |
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| | Ayrault, Olivier [VerfasserIn] |
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| | Remke, Marc [VerfasserIn] |
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| Titel: | The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors |
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| Verf.angabe: | Jasmin Bartl, Marco Zanini, Flavia Bernardi, Antoine Forget, Lena Blümel, Julie Talbot, Daniel Picard, Nan Qin, Gabriele Cancila, Qingsong Gao, Soumav Nath, Idriss Mahoungou Koumba, Marietta Wolter, François Kuonen, Maike Langini, Thomas Beez, Christopher Munoz, David Pauck, Viktoria Marquardt, Hua Yu, Judith Souphron, Mascha Korsch, Christina Mölders, Daniel Berger, Sarah Göbbels, Frauke-Dorothee Meyer, Björn Scheffler, Barak Rotblat, Sven Diederichs, Vijay Ramaswamy, Hiromishi Suzuki, Anthony Oro, Kai Stühler, Anja Stefanski, Ute Fischer, Gabriel Leprivier, Dieter Willbold, Gerhard Steger, Alexander Buell, Marcel Kool, Peter Lichter, Stefan M. Pfister, Paul A. Northcott, Michael D. Taylor, Arndt Borkhardt, Guido Reifenberger, Olivier Ayrault & Marc Remke |
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| E-Jahr: | 2022 |
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| Jahr: | 13 July 2022 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 21.02.2023 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022) vom: Juli, Artikel-ID 4061, Seite 1-15 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Most lncRNAs display species-specific expression patterns suggesting that animal models of cancer may only incompletely recapitulate the regulatory crosstalk between lncRNAs and oncogenic pathways in humans. Among these pathways, Sonic Hedgehog (SHH) signaling is aberrantly activated in several human cancer entities. We unravel that aberrant expression of the primate-specific lncRNA HedgeHog Interacting Protein-AntiSense 1 (HHIP-AS1) is a hallmark of SHH-driven tumors including medulloblastoma and atypical teratoid/rhabdoid tumors. HHIP-AS1 is actively transcribed from a bidirectional promoter shared with SHH regulator HHIP. Knockdown of HHIP-AS1 induces mitotic spindle deregulation impairing tumorigenicity in vitro and in vivo. Mechanistically, HHIP-AS1 binds directly to the mRNA of cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) and attenuates its degradation by hsa-miR-425-5p. We uncover that neither HHIP-AS1 nor the corresponding regulatory element in DYNC1I2 are evolutionary conserved in mice. Taken together, we discover an lncRNA-mediated mechanism that enables the pro-mitotic effects of SHH pathway activation in human tumors. |
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| DOI: | doi:10.1038/s41467-022-31574-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-022-31574-z |
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| | Volltext: https://www.nature.com/articles/s41467-022-31574-z |
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| | DOI: https://doi.org/10.1038/s41467-022-31574-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Long non-coding RNAs |
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| | Mitotic spindle |
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| | Paediatric cancer |
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| K10plus-PPN: | 1837178038 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors / Bartl, Jasmin [VerfasserIn]; 13 July 2022 (Online-Ressource)
