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| Verfasst von: | Bérard, Emilie [VerfasserIn]  |
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| | Röllig, Christoph [VerfasserIn] |
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| | Bertoli, Sarah [VerfasserIn] |
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| | Pigneux, Arnaud [VerfasserIn] |
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| | Tavitian, Suzanne [VerfasserIn] |
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| | Kramer, Michael [VerfasserIn] |
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| | Serve, Hubert [VerfasserIn] |
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| | Bornhäuser, Martin [VerfasserIn] |
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| | Platzbecker, Uwe [VerfasserIn] |
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| | Müller-Tidow, Carsten [VerfasserIn] |
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| | Baldus, Claudia D. [VerfasserIn] |
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| | Martínez-Cuadrón, David [VerfasserIn] |
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| | Serrano, Josefina [VerfasserIn] |
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| | Martínez-Sánchez, Pilar [VerfasserIn] |
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| | Arbolí, Eduardo Rodríguez [VerfasserIn] |
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| | Gil, Cristina [VerfasserIn] |
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| | Bergua, Juan [VerfasserIn] |
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| | Bernal, Teresa [VerfasserIn] |
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| | de la Fuente Burguera, Adolfo [VerfasserIn] |
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| | Delabesse, Eric [VerfasserIn] |
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| | Bidet, Audrey [VerfasserIn] |
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| | Dumas, Pierre-Yves [VerfasserIn] |
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| | Montesinos, Pau [VerfasserIn] |
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| | Recher, Christian [VerfasserIn] |
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| Titel: | A scoring system for AML patients aged 70 years or older, eligible for intensive chemotherapy |
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| Titelzusatz: | a study based on a large European data set using the DATAML, SAL, and PETHEMA registries |
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| Verf.angabe: | Emilie Bérard, Christoph Röllig, Sarah Bertoli, Arnaud Pigneux, Suzanne Tavitian, Michael Kramer, Hubert Serve, Martin Bornhäuser, Uwe Platzbecker, Carsten Müller-Tidow, Claudia D. Baldus, David Martínez-Cuadrón, Josefina Serrano, Pilar Martínez-Sánchez, Eduardo Rodríguez Arbolí, Cristina Gil, Juan Bergua, Teresa Bernal, Adolfo de la Fuente Burguera, Eric Delabesse, Audrey Bidet, Pierre-Yves Dumas, Pau Montesinos and Christian Récher |
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| E-Jahr: | 2022 |
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| Jahr: | 11 July 2022 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 21.02.2023 |
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| Titel Quelle: | Enthalten in: Blood cancer journal |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 12(2022) vom: Juli, Artikel-ID 107, Seite 1-8 |
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| ISSN Quelle: | 2044-5385 |
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| Abstract: | In a context of therapeutic revolution in older adults with AML, it is becoming increasingly important to select patients for the various treatment options by taking account of short-term efficacy and toxicity as well as long-term survival. Here, the data from three European registries for 1,199 AML patients aged 70 years or older treated with intensive chemotherapy were used to develop a prognostic scoring system. The median follow-up was 50.8 months. In the training set of 636 patients, age, performance status, secondary AML, leukocytosis, and cytogenetics, as well as NPM1 mutations (without FLT3-ITD), were all significantly associated with overall survival, albeit not to the same degree. These factors were used to develop a score that predicts long-term overall survival. Three risk-groups were identified: a lower, intermediate and higher-risk score with predicted 5-year overall survival (OS) probabilities of ≥12% (n = 283, 51%; median OS = 18 months), 3-12% (n = 226, 41%; median OS = 9 months) and <3% (n = 47, 8%; median OS = 3 months), respectively. This scoring system was also significantly associated with complete remission, early death and relapse-free survival; performed similarly in the external validation cohort (n = 563) and showed a lower false-positive rate than previously published scores. The European Scoring System ≥70, easy for routine calculation, predicts long-term survival in older AML patients considered for intensive chemotherapy. |
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| DOI: | doi:10.1038/s41408-022-00700-x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41408-022-00700-x |
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| | Volltext: https://www.nature.com/articles/s41408-022-00700-x |
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| | DOI: https://doi.org/10.1038/s41408-022-00700-x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Acute myeloid leukaemia |
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| | Risk factors |
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| K10plus-PPN: | 1837178801 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ scoring system for AML patients aged 70 years or older, eligible for intensive chemotherapy / Bérard, Emilie [VerfasserIn]; 11 July 2022 (Online-Ressource)
