| |  Online-Ressource |
|---|
| Verfasst von: | Franciotta, Diego [VerfasserIn]  |
|---|
| | Di Stefano, Anna Luisa [VerfasserIn] |
|---|
| | Jarius, Sven [VerfasserIn] |
|---|
| | Zardini, Elisabetta [VerfasserIn] |
|---|
| | Tavazzi, Eleonora [VerfasserIn] |
|---|
| | Ballerini, Clara [VerfasserIn] |
|---|
| | Marchioni, Enrico [VerfasserIn] |
|---|
| | Bergamaschi, Roberto [VerfasserIn] |
|---|
| | Ceroni, Mauro [VerfasserIn] |
|---|
| Titel: | Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases |
|---|
| Verf.angabe: | Diego Franciotta, Anna Luisa Di Stefano, Sven Jarius, Elisabetta Zardini, Eleonora Tavazzi, Clara Ballerini, Enrico Marchioni, Roberto Bergamaschi, Mauro Ceroni |
|---|
| Jahr: | 2011 |
|---|
| Umfang: | 4 S. |
|---|
| Fussnoten: | Online verfügbar 24 November 2010 ; Gesehen am 21.02.2023 |
|---|
| Titel Quelle: | Enthalten in: Journal of neuroimmunology |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1981 |
|---|
| Jahr Quelle: | 2011 |
|---|
| Band/Heft Quelle: | 230(2011), 1/2 vom: Jan., Seite 160-163 |
|---|
| ISSN Quelle: | 1872-8421 |
|---|
| Abstract: | We measured circulating serum and cerebrospinal fluid (CSF) concentrations of B lymphocyte activating factor of the tumour necrosis factor superfamily (BAFF), and determined total and Epstein-Barr virus (EBV)-specific oligoclonal IgG bands (OCBs) in 43 patients with multiple sclerosis (MS), 23 patients with other inflammatory demyelinating neurological diseases, and 20 patients with non-inflammatory neurological diseases. Serum and CSF BAFF concentrations did not differ in the three studied groups. In MS, the highest BAFF concentrations were found in the CSF samples with more than 6 OCBs (233.1±129.5 vs 79.2±51.6pg/mL in the samples with less than 7 OCBs, p<0.0001). Irrespectively from BAFF levels, EBV-specific OCBs were detected in MS and in the other non-inflammatory and inflammatory demyelinating neurological diseases, with a similar frequency, and as a ‘mirror pattern’ in 30 of 33 EBV-specific OCB-positive cases (p<0.0001). These results indicate that circulating CSF BAFF concentrations cannot help differentiate MS from other inflammatory demyelinating neurological diseases, but positively associates with the qualitative expression of elevated intrathecal IgG production in MS, and that the oligoclonal EBV-specific antibody response, when present, is mostly systemic in all the studied neurological patients, and not preferentially restricted to MS. |
|---|
| DOI: | doi:10.1016/j.jneuroim.2010.10.027 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jneuroim.2010.10.027 |
|---|
| | Volltext: https://www.sciencedirect.com/science/article/pii/S0165572810004777 |
|---|
| | DOI: https://doi.org/10.1016/j.jneuroim.2010.10.027 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Acute disseminated encephalomyelitis |
|---|
| | BAFF |
|---|
| | Cerebrospinal fluid |
|---|
| | Epstein-Barr virus |
|---|
| | Multiple sclerosis |
|---|
| | Neuromyelitis optica |
|---|
| K10plus-PPN: | 1837185794 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases / Franciotta, Diego [VerfasserIn]; 2011 (Online-Ressource)
