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| Verfasst von: | Schneider, Kai Markus [VerfasserIn]  |
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| | Mohs, Antje [VerfasserIn] |
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| | Gui, Wenfang [VerfasserIn] |
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| | Galvez, Eric J. C. [VerfasserIn] |
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| | Candels, Lena Susanna [VerfasserIn] |
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| | Hoenicke, Lisa [VerfasserIn] |
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| | Muthukumarasamy, Uthayakumar [VerfasserIn] |
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| | Holland, Christian H. [VerfasserIn] |
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| | Elfers, Carsten [VerfasserIn] |
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| | Kilic, Konrad [VerfasserIn] |
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| | Schneider, Carolin Victoria [VerfasserIn] |
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| | Schierwagen, Robert [VerfasserIn] |
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| | Strnad, Pavel [VerfasserIn] |
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| | Wirtz, Theresa H. [VerfasserIn] |
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| | Marschall, Hanns-Ulrich [VerfasserIn] |
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| | Latz, Eicke [VerfasserIn] |
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| | Lelouvier, Benjamin [VerfasserIn] |
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| | Sáez Rodríguez, Julio [VerfasserIn] |
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| | de Vos, Willem [VerfasserIn] |
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| | Strowig, Till [VerfasserIn] |
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| | Trebicka, Jonel [VerfasserIn] |
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| | Trautwein, Christian [VerfasserIn] |
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| Titel: | Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment |
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| Verf.angabe: | Kai Markus Schneider, Antje Mohs, Wenfang Gui, Eric J. C. Galvez, Lena Susanna Candels, Lisa Hoenicke, Uthayakumar Muthukumarasamy, Christian H. Holland, Carsten Elfers, Konrad Kilic, Carolin Victoria Schneider, Robert Schierwagen, Pavel Strnad, Theresa H. Wirtz, Hanns-Ulrich Marschall, Eicke Latz, Benjamin Lelouvier, Julio Saez-Rodriguez, Willem de Vos, Till Strowig, Jonel Trebicka & Christian Trautwein |
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| E-Jahr: | 2022 |
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| Jahr: | 08 July 2022 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 21.02.2023 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022) vom: Juli, Artikel-ID 3964, Seite 1-19 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and therapeutic options for advanced HCC are limited. Here, we observe that intestinal dysbiosis affects antitumor immune surveillance and drives liver disease progression towards cancer. Dysbiotic microbiota, as seen in Nlrp6−/− mice, induces a Toll-like receptor 4 dependent expansion of hepatic monocytic myeloid-derived suppressor cells (mMDSC) and suppression of T-cell abundance. This phenotype is transmissible via fecal microbiota transfer and reversible upon antibiotic treatment, pointing to the high plasticity of the tumor microenvironment. While loss of Akkermansia muciniphila correlates with mMDSC abundance, its reintroduction restores intestinal barrier function and strongly reduces liver inflammation and fibrosis. Cirrhosis patients display increased bacterial abundance in hepatic tissue, which induces pronounced transcriptional changes, including activation of fibro-inflammatory pathways as well as circuits mediating cancer immunosuppression. This study demonstrates that gut microbiota closely shapes the hepatic inflammatory microenvironment opening approaches for cancer prevention and therapy. |
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| DOI: | doi:10.1038/s41467-022-31312-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-022-31312-5 |
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| | Volltext: https://www.nature.com/articles/s41467-022-31312-5 |
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| | DOI: https://doi.org/10.1038/s41467-022-31312-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Hepatocellular carcinoma |
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| | Microbiome |
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| | Tumour immunology |
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| K10plus-PPN: | 1837203741 |
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| Verknüpfungen: | → Zeitschrift |
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Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment / Schneider, Kai Markus [VerfasserIn]; 08 July 2022 (Online-Ressource)
