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| Verfasst von: | Brenner, Thorsten [VerfasserIn]  |
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| | Rosenhagen, Claudia [VerfasserIn] |
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| | Steppan, Jochen [VerfasserIn] |
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| | Lichtenstern, Christoph [VerfasserIn] |
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| | Weitz, Jürgen [VerfasserIn] |
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| | Bruckner, Thomas [VerfasserIn] |
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| | Martin, Eike [VerfasserIn] |
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| | Hoffmann, Ursula [VerfasserIn] |
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| | Weigand, Markus A. [VerfasserIn] |
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| | Hofer, Stefan [VerfasserIn] |
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| Titel: | Redox responses in patients with sepsis |
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| Titelzusatz: | high correlation of Thioredoxin-1 and macrophage migration inhibitory factor plasma levels |
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| Verf.angabe: | Thorsten Brenner, Claudia Rosenhagen, Jochen Steppan, Christoph Lichtenstern, Jürgen Weitz, Thomas Bruckner, Eike O. Martin, Ursula Hoffmann, Markus A. Weigand, and Stefan Hofer |
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| E-Jahr: | 2010 |
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| Jahr: | 05 Aug 2010 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 24.02.2023 |
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| Titel Quelle: | Enthalten in: Mediators of inflammation |
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| Ort Quelle: | Sylvania, Ohio : Hindawi Publishing Corp., 1992 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 2010(2010), Artikel-ID e985614, Seite 1-8 |
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| ISSN Quelle: | 1466-1861 |
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| Abstract: | Background. Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods. Blood samples from patients with severe sepsis or septic shock ( ) were collected at the time of sepsis diagnosis (t0), and 24 (t24) and 48 (t48) hours later; samples from healthy volunteers ( ) were collected once; samples from postoperative patients ( ) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results. The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation (t0: : ). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response. |
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| DOI: | doi:10.1155/2010/985614 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1155/2010/985614 |
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| | Volltext: https://www.hindawi.com/journals/mi/2010/985614/ |
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| | DOI: https://doi.org/10.1155/2010/985614 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1837401349 |
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| Verknüpfungen: | → Zeitschrift |
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Redox responses in patients with sepsis / Brenner, Thorsten [VerfasserIn]; 05 Aug 2010 (Online-Ressource)
