| |  Online-Ressource |
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| Verfasst von: | Frankenstein, Lutz [VerfasserIn]  |
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| | Goode, K. [VerfasserIn] |
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| | Ingle, L. [VerfasserIn] |
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| | Remppis, Bjoern-Andrew [VerfasserIn] |
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| | Schellberg, Dieter [VerfasserIn] |
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| | Nelles, Manfred [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Clark, A. L. [VerfasserIn] |
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| | Cleland, J. G. F. [VerfasserIn] |
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| | Zugck, Christian [VerfasserIn] |
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| Titel: | Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers? |
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| Verf.angabe: | L. Frankenstein, K. Goode, L. Ingle, A. Remppis, D. Schellberg, M. Nelles, H.A. Katus, A.L. Clark, J.G.F. Cleland, C. Zugck |
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| Jahr: | 2011 |
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| Umfang: | 5 S. |
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| Fussnoten: | Online verfügbar 17. September 2009 ; Gesehen am 27.02.2023 |
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| Titel Quelle: | Enthalten in: International journal of cardiology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1981 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 147(2011), 1 vom: Feb., Seite 74-78 |
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| ISSN Quelle: | 1874-1754 |
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| Abstract: | Background: It is unclear whether risk prediction strategies in chronic heart failure (CHF) need to be specific for sex or beta-blockers. We examined this problem and developed and validated the consequent risk models based on 6-minute-walk-test and NT-proBNP. Methods: The derivation cohort comprised 636 German patients with systolic dysfunction. They were validated against 676 British patients with similar aetiology. ROC-curves for 1-year mortality identified cut-off values separately for specificity (none, sex, beta-blocker, both). Patients were grouped according to number of cut-offs met (group I/II/III - 0/1/2 cut-offs). Results: Widest separation between groups was achieved with sex- and beta-blocker-specific cut offs. In the derivation population, 1-year mortality was 0%, 8%, 31% for group I, II and III, respectively. In the validation population, 1-year rates in the three risk groups were 2%, 7%, 14%, respectively, after application of the same cut-offs. Conclusion: Risk stratification for CHF should perhaps take sex and beta-blocker usage into account. We derived and independently validated relevant risk models based on 6-minute-walk-tests and NT-proBNP. Specifying sex and use of beta-blockers identified three distinct sub-groups with widely differing prognosis. In clinical practice, it may be appropriate to tailor the intensity of follow-up and/or the treatment strategy according to the risk-group. |
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| DOI: | doi:10.1016/j.ijcard.2009.08.005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ijcard.2009.08.005 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0167527309008547 |
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| | DOI: https://doi.org/10.1016/j.ijcard.2009.08.005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Beta-blockers |
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| | Chronic heart failure |
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| | Risk prediction |
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| | Sex |
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| K10plus-PPN: | 183757202X |
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| Verknüpfungen: | → Zeitschrift |
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Derivation and validation of a simple clinical risk-model in heart failure based on 6 minute walk test performance and NT-proBNP status - Do we need specificity for sex and beta-blockers? / Frankenstein, Lutz [VerfasserIn]; 2011 (Online-Ressource)
