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Status: Bibliographieeintrag

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Verfasst von:Loi, Lisa [VerfasserIn]   i
 Görke, Steffen [VerfasserIn]   i
 Zimmermann, Ferdinand [VerfasserIn]   i
 Korzowski, Andreas [VerfasserIn]   i
 Meißner, Jan-Eric [VerfasserIn]   i
 Breitling, Johannes [VerfasserIn]   i
 Schott, Sarah [VerfasserIn]   i
 Bachert, Peter [VerfasserIn]   i
 Ladd, Mark E. [VerfasserIn]   i
 Schlemmer, Heinz-Peter [VerfasserIn]   i
 Bickelhaupt, Sebastian [VerfasserIn]   i
 Paech, Daniel [VerfasserIn]   i
Titel:Assessing the influence of the menstrual cycle on APT CEST-MRI in the human breast
Verf.angabe:Lisa Loi, Steffen Görke, Ferdinand Zimmermann, Andreas Korzowski, Jan-Eric Meißner, Johannes Breitling, Sarah Schott, Peter Bachert, Mark E. Ladd, Heinz-Peter Schlemmer, Sebastian Bickelhaupt, Daniel Paech
E-Jahr:2022
Jahr:September 2022
Umfang:8 S.
Fussnoten:Gesehen am 01.03.2023
Titel Quelle:Enthalten in: Magnetic resonance imaging
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1982
Jahr Quelle:2022
Band/Heft Quelle:91(2022), Seite 24-31
ISSN Quelle:1873-5894
Abstract:Purpose: In fibroglandular breast tissue, conventional dynamic contrast-enhanced MR-mammography is known to be affected by water content changes during the menstrual cycle. Likewise, amide proton transfer (APT) chemical exchange saturation transfer (CEST)-MRI might be inherently prone to the menstrual cycle, as CEST signals are indirectly detected via the water signal. The purpose of this study was to investigate the influence of the menstrual cycle on APT CEST-MRI in fibroglandular breast tissue. Method: Ten healthy premenopausal women (19-34 years) were included in this IRB approved prospective study and examined twice during their menstrual cycle. Examination one and two were performed during the first half (day 2-8) and the second half (day 15-21) of the menstrual cycle, respectively. As a reference for the APT signal in malignant breast tumor tissue, previously reported data of nine breast cancer patients were included in this study. CEST-MRI (B1 = 0.7 mu T) was performed on a 7 T whole-body scanner followed by a multi-Lorentzian fit analysis. The APT signal was corrected for B0/B1-field inhomogeneities, fat signal contribution, and relaxation effects of the water signal and evaluated in the fibroglandular breast tissue. Intra-individual APT signal differences between examination one and two were compared using the Wilcoxon signed-rank test. The level of significance was set at p < 0.05. Results: The APT signal showed no significant difference in the fibroglandular breast tissue of healthy premenopausal volunteers throughout the menstrual cycle (p = 1.00) (examination 1 vs. examination 2: mean and standard deviation = 3.24 +/- 0.68%Hz vs. 3.30 +/- 0.73%Hz, median and IQR = 3.36%Hz and 0.87%Hz vs. 3.38% Hz and 0.71%Hz). Conclusion: The present study provides an important basis for the clinical application of APT CEST-MRI as an additional contrast mechanism in MR-mammography, as menstrual cycle-related APT signal fluctuations seem to be negligible compared to the APT signal increase in breast cancer tissue.
DOI:doi:10.1016/j.mri.2022.05.006
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.mri.2022.05.006
 Volltext: https://linkinghub.elsevier.com/retrieve/pii/S0730725X22000716
 DOI: https://doi.org/10.1016/j.mri.2022.05.006
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:3 t
 apparent diffusion-coefficient
 apt
 arex
 background parenchymal enhancement
 cest
 contrast-medium enhancement
 dixon
 Fat correction
 Mammography
 Menstrual cycle
 reproducibility
 signals
 tesla
 tissue
 water
K10plus-PPN:183780110X
Verknüpfungen:→ Zeitschrift

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