Sporadic cases of acute autochthonous hepatitis E virus infection in Southwest Germany

• Verfasst von: Brost, Sylvia [VerfasserIn]
• Verfasst von: Wenzel, J. J. [VerfasserIn]
• Verfasst von: Ganten, Tom M. [VerfasserIn]
• Verfasst von: Filser, Michael [VerfasserIn]
• Verfasst von: Flechtenmacher, Christa [VerfasserIn]
• Verfasst von: Boehm, S. [VerfasserIn]
• Verfasst von: Astani, Akram [VerfasserIn]
• Verfasst von: Jilg, W. [VerfasserIn]
• Verfasst von: Zeier, Martin [VerfasserIn]
• Verfasst von: Schnitzler, Paul [VerfasserIn]
• Titel: Sporadic cases of acute autochthonous hepatitis E virus infection in Southwest Germany
• Verf.angabe: S. Brost, J.J. Wenzel, T.M. Ganten, M. Filser, C. Flechtenmacher, S. Boehm, A. Astani, W. Jilg, M. Zeier, P. Schnitzler
• Jahr: 2010
• Umfang: 4 S.
• Fussnoten: Erstmals am 11. November 2009 online veröffentlicht ; Gesehen am 01.03.2023
• Titel Quelle: Enthalten in: Clinical and diagnostic virology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1993
• Jahr Quelle: 2010
• Band/Heft Quelle: 47(2010), 1 vom: Jan., Seite 89-92
• ISSN Quelle: 1873-4901
• DOI: doi:10.1016/j.jcv.2009.10.011
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Acute hepatitis
• Sach-SW: Autochthonous hepatitis E
• Sach-SW: Hepatitis E virus
• Sach-SW: HEV
• K10plus-PPN: 1837834040

Abstract

Hepatitis E infection is usually a self-limiting disease and an important cause of acute hepatitis in tropical and subtropical regions where the virus is endemic. In industrialized countries, sporadic cases of acute hepatitis E virus (HEV) infections have been described and the number of documented autochthonous infections seems to be increasing. We report three sporadic cases of autochthonous hepatitis E infections in Southwestern Germany which presented at our university hospital within two years. All cases were men who presented with acute hepatitis, icterus and elevated liver. In case 1 and case 2, liver biopsy revealed acute hepatitis, both patients were positive for anti-HEV antibodies, case 1 was also positive for HEV RNA with a viral load of 3.0×103copies/ml in serum. In case 3, anti-HEV antibodies were detectable and HEV RNA was detected in serum (4.3×103copies/ml) and stool (1.4×106copies/ml). None of the patients had a recent travel history outside Germany and close contact to animals has been denied. HEV sequence analysis of two patients revealed genotype 3 with homologies to other European isolates and isolates from swine. Thus the source of infection remains unclear. Hepatitis E should be considered in differential diagnosis in patients with unexplained hepatitis and patients with acute hepatitis, whatever their age or travel history might be, should be tested for HEV.