| |  Online-Ressource |
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| Verfasst von: | Broyl, Annemiek [VerfasserIn]  |
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| | Hose, Dirk [VerfasserIn] |
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| | Lokhorst, Henk [VerfasserIn] |
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| | Knegt, Yvonne de [VerfasserIn] |
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| | Peeters, Justine [VerfasserIn] |
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| | Jauch, Anna [VerfasserIn] |
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| | Bertsch, Uta [VerfasserIn] |
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| | Buijs, Arjan [VerfasserIn] |
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| | Stevens-Kroef, Marian [VerfasserIn] |
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| | Beverloo, H. Berna [VerfasserIn] |
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| | Vellenga, Edo [VerfasserIn] |
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| | Zweegman, Sonja [VerfasserIn] |
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| | Kersten, Marie-Josée [VerfasserIn] |
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| | Van der Holt, Bronno [VerfasserIn] |
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| | Jarari, Laila El [VerfasserIn] |
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| | Mulligan, George [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| | Duin, Mark van [VerfasserIn] |
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| | Sonneveld, Pieter [VerfasserIn] |
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| Titel: | Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients |
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| Verf.angabe: | Annemiek Broyl, Dirk Hose, Henk Lokhorst, Yvonne de Knegt, Justine Peeters, Anna Jauch, Uta Bertsch, Arjan Buijs, Marian Stevens-Kroef, H. Berna Beverloo, Edo Vellenga, Sonja Zweegman, Marie-Josée Kersten, Bronno van der Holt, Laila el Jarari, George Mulligan, Hartmut Goldschmidt, Mark van Duin, and Pieter Sonneveld |
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| E-Jahr: | 2010 |
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| Jahr: | October 7, 2010 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 02.03.2023 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 116(2010), 14, Seite 2543-2553 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138+ plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded to clusters described in the University of Arkansas for Medical Science (UAMS) classification, CD-1 (n = 13, 4.1%), CD-2 (n = 34, 1.6%), MF (n = 32, 1.0%), MS (n = 33, 1.3%), proliferation-associated genes (n = 15, 4.7%), and hyperdiploid (n = 77, 24.1%). Moreover, the UAMS low percentage of bone disease cluster was identified as a subcluster of the MF cluster (n = 15, 4.7%). One subgroup (n = 39, 12.2%) showed a myeloid signature. Three novel subgroups were defined, including a subgroup of 37 patients (11.6%) characterized by high expression of genes involved in the nuclear factor kappa light-chain-enhancer of activated B cells pathway, which include TNFAIP3 and CD40. Another subgroup of 22 patients (6.9%) was characterized by distinct overexpression of cancer testis antigens without overexpression of proliferation genes. The third novel cluster of 9 patients (2.8%) showed up-regulation of protein tyrosine phosphatases PRL-3 and PTPRZ1 as well as SOCS3. To conclude, in addition to 7 clusters described in the UAMS classification, we identified 3 novel subsets of multiple myeloma that may represent unique diagnostic entities. |
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| DOI: | doi:10.1182/blood-2009-12-261032 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood-2009-12-261032 |
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| | DOI: https://doi.org/10.1182/blood-2009-12-261032 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1837913072 |
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| Verknüpfungen: | → Zeitschrift |
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Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients / Broyl, Annemiek [VerfasserIn]; October 7, 2010 (Online-Ressource)
