| Online-Ressource |
Verfasst von: | Broyl, Annemiek [VerfasserIn]  |
| Hose, Dirk [VerfasserIn]  |
| Lokhorst, Henk [VerfasserIn]  |
| Knegt, Yvonne de [VerfasserIn]  |
| Peeters, Justine [VerfasserIn]  |
| Jauch, Anna [VerfasserIn]  |
| Bertsch, Uta [VerfasserIn]  |
| Buijs, Arjan [VerfasserIn]  |
| Stevens-Kroef, Marian [VerfasserIn]  |
| Beverloo, H. Berna [VerfasserIn]  |
| Vellenga, Edo [VerfasserIn]  |
| Zweegman, Sonja [VerfasserIn]  |
| Kersten, Marie-Josée [VerfasserIn]  |
| Van der Holt, Bronno [VerfasserIn]  |
| Jarari, Laila El [VerfasserIn]  |
| Mulligan, George [VerfasserIn]  |
| Goldschmidt, Hartmut [VerfasserIn]  |
| Duin, Mark van [VerfasserIn]  |
| Sonneveld, Pieter [VerfasserIn]  |
Titel: | Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients |
Verf.angabe: | Annemiek Broyl, Dirk Hose, Henk Lokhorst, Yvonne de Knegt, Justine Peeters, Anna Jauch, Uta Bertsch, Arjan Buijs, Marian Stevens-Kroef, H. Berna Beverloo, Edo Vellenga, Sonja Zweegman, Marie-Josée Kersten, Bronno van der Holt, Laila el Jarari, George Mulligan, Hartmut Goldschmidt, Mark van Duin, and Pieter Sonneveld |
E-Jahr: | 2010 |
Jahr: | October 7, 2010 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 02.03.2023 |
Titel Quelle: | Enthalten in: Blood |
Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 116(2010), 14, Seite 2543-2553 |
ISSN Quelle: | 1528-0020 |
Abstract: | To identify molecularly defined subgroups in multiple myeloma, gene expression profiling was performed on purified CD138+ plasma cells of 320 newly diagnosed myeloma patients included in the Dutch-Belgian/German HOVON-65/GMMG-HD4 trial. Hierarchical clustering identified 10 subgroups; 6 corresponded to clusters described in the University of Arkansas for Medical Science (UAMS) classification, CD-1 (n = 13, 4.1%), CD-2 (n = 34, 1.6%), MF (n = 32, 1.0%), MS (n = 33, 1.3%), proliferation-associated genes (n = 15, 4.7%), and hyperdiploid (n = 77, 24.1%). Moreover, the UAMS low percentage of bone disease cluster was identified as a subcluster of the MF cluster (n = 15, 4.7%). One subgroup (n = 39, 12.2%) showed a myeloid signature. Three novel subgroups were defined, including a subgroup of 37 patients (11.6%) characterized by high expression of genes involved in the nuclear factor kappa light-chain-enhancer of activated B cells pathway, which include TNFAIP3 and CD40. Another subgroup of 22 patients (6.9%) was characterized by distinct overexpression of cancer testis antigens without overexpression of proliferation genes. The third novel cluster of 9 patients (2.8%) showed up-regulation of protein tyrosine phosphatases PRL-3 and PTPRZ1 as well as SOCS3. To conclude, in addition to 7 clusters described in the UAMS classification, we identified 3 novel subsets of multiple myeloma that may represent unique diagnostic entities. |
DOI: | doi:10.1182/blood-2009-12-261032 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood-2009-12-261032 |
| DOI: https://doi.org/10.1182/blood-2009-12-261032 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1837913072 |
Verknüpfungen: | → Zeitschrift |
Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients / Broyl, Annemiek [VerfasserIn]; October 7, 2010 (Online-Ressource)