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| Verfasst von: | Kristen, Arnt [VerfasserIn]  |
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| | Schnabel, Philipp Albert [VerfasserIn] |
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| | Winter, Bettina [VerfasserIn] |
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| | Helmke, Burkhard Maria [VerfasserIn] |
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| | Longerich, Thomas [VerfasserIn] |
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| | Hardt, Stefan [VerfasserIn] |
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| | Koch, Achim [VerfasserIn] |
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| | Sack, Falk-Udo [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Linke, Reinhold P. [VerfasserIn] |
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| | Dengler, Thomas [VerfasserIn] |
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| Titel: | High prevalence of amyloid in 150 surgically removed heart valves - a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions |
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| Verf.angabe: | Arnt V. Kristen, Philipp A. Schnabel, Bettina Winter, Burkhard M. Helmke, Thomas Longerich, Stefan Hardt, Achim Koch, Falk-Udo Sack, Hugo A. Katus, Reinhold P. Linke, Thomas J. Dengler |
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| E-Jahr: | 2010 |
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| Jahr: | 8 June 2009 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 03.03.2023 |
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| Titel Quelle: | Enthalten in: Cardiovascular pathology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1992 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 19(2010), 4, Seite 228-235 |
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| ISSN Quelle: | 1879-1336 |
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| Abstract: | Introduction - The prevalence, pathophysiology, and clinical indicators of valvular amyloid deposition have not been clarified yet. - Methods - One hundred fifty surgically resected heart valve specimens [67.4±1.0 years; aortic stenosis (AS), n=100; aortic regurgitation, n=19; mitral stenosis, n=7; mitral regurgitation, n=24] were qualitatively, semiquantitatively, and immunohistochemically analyzed and correlated with clinical data. - Results - Amyloid was found in 83/150 specimens with highest prevalence in AS (74/100), intermediate prevalence in mitral stenosis (2/7) and regurgitation (7/24), and lowest prevalence in aortic regurgitation (2/19). Severe and polymorphic amyloid deposits were almost exclusively found in AS (35/100). Filamentous cloudy amyloid patterns occurred with the same frequency in AS (29/100). A combination of both was found only in AS (n=7/100). By immunohistochemistry, none of the most common amyloid proteins was identified except for a weak staining by the apolipoprotein AI antibody, but more intense adjacent to amyloid deposits. Amyloid correlated with valvular thickening (P<.05), hyperlipidemia (P=.07), coronary artery disease (P=.084), and obesity (P=.082). - Conclusions - Localized valvular amyloid is predominantly found in stenotic aortic valves. It appears to depend on atheroinflammatory conditions and high shear-stress hemodynamics. Further studies are needed to identify the underlying protein. |
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| DOI: | doi:10.1016/j.carpath.2009.04.005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.carpath.2009.04.005 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1054880709000350 |
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| | DOI: https://doi.org/10.1016/j.carpath.2009.04.005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Amyloid |
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| | Apolipoprotein AI |
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| | Atherosclerosis |
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| | Heart valves |
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| | Hyperlipidemia |
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| | Immunohistochemistry |
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| K10plus-PPN: | 1838118373 |
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| Verknüpfungen: | → Zeitschrift |
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High prevalence of amyloid in 150 surgically removed heart valves - a comparison of histological and clinical data reveals a correlation to atheroinflammatory conditions / Kristen, Arnt [VerfasserIn]; 8 June 2009 (Online-Ressource)
