Synthesis and characterization of dual modality (CT/MRI) core-shell microparticles for embolization purposes

• Verfasst von: Hagit, Aviv [VerfasserIn]
• Verfasst von: Bartling, Sönke [VerfasserIn]
• Verfasst von: Budjan, Johannes [VerfasserIn]
• Verfasst von: Margel, Shlomo [VerfasserIn]
• Titel: Synthesis and characterization of dual modality (CT/MRI) core-shell microparticles for embolization purposes
• Verf.angabe: Aviv Hagit, Bartling Soenke, Budjan Johannes, and Margel Shlomo
• E-Jahr: 2010
• Jahr: May 5, 2010
• Umfang: 8 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 03.03.2023
• Titel Quelle: Enthalten in: Biomacromolecules
• Ort Quelle: Columbus, Ohio : American Chemical Soc., 2000
• Jahr Quelle: 2010
• Band/Heft Quelle: 11(2010), 6 vom: Mai, Seite 1600-1607
• ISSN Quelle: 1526-4602
• DOI: doi:10.1021/bm100251s
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1838143114

Abstract

Core P(MAOETIB-GMA) microparticles of 40−200 μm were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic γ-Fe2O3/P(MAOETIB-GMA) core−shell microparticles were prepared by coating the aforementioned core particles through nucleation of iron oxide nanoparticles on the surfaces of the P(MAOETIB-GMA) particles. This was followed by stepwise growth of thin iron oxide layers. The radiopacity and magnetism of these particles were demonstrated in vitro by CT and MRI. In vivo embolization capabilities of these first multimodal visible embolization particles were demonstrated in a rat’s kidney tumor embolization model.