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Verfasst von:Chen, Ying [VerfasserIn]   i
 Löhr, J.-Matthias [VerfasserIn]   i
 Jesenofsky, Ralf [VerfasserIn]   i
Titel:Inhibition of ankyrin-B expression reduces growth and invasion of human pancreatic ductal adenocarcinoma
Verf.angabe:Ying Chen, Matthias Löhr, Ralf Jesnowski
E-Jahr:2010
Jahr:October 30, 2010
Umfang:11 S.
Fussnoten:Gesehen am 03.03.2023
Titel Quelle:Enthalten in: Pancreatology
Ort Quelle:Amsterdam : Elsevier, 2001
Jahr Quelle:2010
Band/Heft Quelle:10(2010), 5, Seite 586-596
ISSN Quelle:1424-3911
Abstract:BACKGROUND: In spite of the increasing knowledge of the molecular pathology of pancreatic ductal adenocarcinoma (PDAC), treatment of this tumor still remains an unresolved problem. Thus, the identification of 'novel' genes involved in pancreatic tumor progression is essential for early diagnosis and new treatment regimens of PDAC. Ankyrin-B (ANK2) was identified as being overexpressed in PDAC in a previous study by our group. ANK2 overexpression has been described in several tumors; however, the function of ANK2 in pancreatic carcinoma has not been elucidated. - MATERIALS AND METHODS: In the present study, we confirmed ANK2 overexpression in PDAC and analyzed the effects of ANK2 knockdown in the pancreatic tumor cell line PANC-1. - RESULTS: ANK2 silencing reduced the activity of FAK, ERK1/2 and p38. Decreased ANK2 expression restrained migration and invasive potential of PANC-1 cells. Moreover, silencing of ANK2 decreased the proliferation of the pancreatic tumor cells and reduced their tumorigenicity in vitro and in vivo. - CONCLUSION: Our results demonstrate that silencing of ANK2 expression reduced the malignant phenotype of pancreatic cancer cells, indicating that ANK2 represents a potential target for therapy of pancreatic cancer.
DOI:doi:10.1159/000308821
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000308821
 DOI: https://doi.org/10.1159/000308821
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adenocarcinoma
 Ankyrins
 Carcinoma, Pancreatic Ductal
 Cell Line, Tumor
 Cell Movement
 Cell Proliferation
 Humans
 Neoplasm Invasiveness
 Pancreatic Neoplasms
 RNA Interference
K10plus-PPN:1838144552
Verknüpfungen:→ Zeitschrift

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