| Online-Ressource |
Verfasst von: | Hammer, Christian [VerfasserIn]  |
| Fasching, Peter Andreas [VerfasserIn]  |
| Loehberg, Christian R [VerfasserIn]  |
| Rauh, Claudia [VerfasserIn]  |
| Ekici, Arif B. [VerfasserIn]  |
| Jud, Sebastian M. [VerfasserIn]  |
| Bani, Mayada R. [VerfasserIn]  |
| Beckmann, Matthias Wilhelm [VerfasserIn]  |
| Strick, Reiner [VerfasserIn]  |
| Niesler, Beate [VerfasserIn]  |
Titel: | Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy |
Verf.angabe: | Christian Hammer, Peter A. Fasching, Christian R. Loehberg, Claudia Rauh, Arif B. Ekici, Sebastian M. Jud, Mayada R. Bani, Matthias W. Beckmann, Reiner Strick & Beate Niesler |
E-Jahr: | 2010 |
Jahr: | 6 Jul 2010 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 03.03.2023 |
Titel Quelle: | Enthalten in: Pharmacogenomics |
Ort Quelle: | London [u.a.] : Ashley, 2000 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 11(2010), 7 vom: Juli, Seite 943-950 |
ISSN Quelle: | 1744-8042 |
Abstract: | Aims: Serotonin (5-hydroxytryptamine 3; 5-HT3) receptors are involved in chemotherapy-induced nausea and vomiting (CINV), and 5-HT3 antagonists are part of the ‘gold standard’ antiemetic treatment during chemotherapy. We investigated the correlation of common variants in 5-HT3 receptor subunit genes with the occurrence of CINV. Materials & methods: A total of 110 previously characterized chemotherapy-naive women with primary breast cancer treated with anthracycline-containing chemotherapy served as a study group for mutational analysis by direct sequencing. Eight common SNPs in the 5-HT3 receptor genes, HTR3A, HTR3B, HTR3D and HTR3E, were selected for association analysis. Results: A nonsynonymous variant in HTR3D, p.G36A (rs6443930), was found to be over-represented in nonresponders, assuming a log-additive inheritance model (p = 0.048). Cox proportional regression analysis resulted in a hazards ratio of 0.36 for homozygous carriers of the C allele to vomit within 24 h after first chemotherapy administration (p = 0.049). Conclusion: Our data supports the hypothesis that 5-HT3 receptors play an important role in the pathogenesis of CINV. Along with previously identified HTR3 polymorphisms, the HTR3D p.G36A variant could also contribute to facilitating individual risk predictions. |
DOI: | doi:10.2217/pgs.10.67 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.2217/pgs.10.67 |
| Volltext: https://www.futuremedicine.com/doi/10.2217/pgs.10.67 |
| DOI: https://doi.org/10.2217/pgs.10.67 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | 5-HT3 |
| breast cancer |
| chemotherapy-induced nausea and vomiting |
| CINV |
| HTR3 |
| pharmacogenomics |
| serotonin |
| SNP |
K10plus-PPN: | 1838155473 |
Verknüpfungen: | → Zeitschrift |
Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy / Hammer, Christian [VerfasserIn]; 6 Jul 2010 (Online-Ressource)