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Verfasst von:Hammer, Christian [VerfasserIn]   i
 Fasching, Peter Andreas [VerfasserIn]   i
 Loehberg, Christian R [VerfasserIn]   i
 Rauh, Claudia [VerfasserIn]   i
 Ekici, Arif B. [VerfasserIn]   i
 Jud, Sebastian M. [VerfasserIn]   i
 Bani, Mayada R. [VerfasserIn]   i
 Beckmann, Matthias Wilhelm [VerfasserIn]   i
 Strick, Reiner [VerfasserIn]   i
 Niesler, Beate [VerfasserIn]   i
Titel:Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy
Verf.angabe:Christian Hammer, Peter A. Fasching, Christian R. Loehberg, Claudia Rauh, Arif B. Ekici, Sebastian M. Jud, Mayada R. Bani, Matthias W. Beckmann, Reiner Strick & Beate Niesler
E-Jahr:2010
Jahr:6 Jul 2010
Umfang:8 S.
Fussnoten:Gesehen am 03.03.2023
Titel Quelle:Enthalten in: Pharmacogenomics
Ort Quelle:London [u.a.] : Ashley, 2000
Jahr Quelle:2010
Band/Heft Quelle:11(2010), 7 vom: Juli, Seite 943-950
ISSN Quelle:1744-8042
Abstract:Aims: Serotonin (5-hydroxytryptamine 3; 5-HT3) receptors are involved in chemotherapy-induced nausea and vomiting (CINV), and 5-HT3 antagonists are part of the ‘gold standard’ antiemetic treatment during chemotherapy. We investigated the correlation of common variants in 5-HT3 receptor subunit genes with the occurrence of CINV. Materials & methods: A total of 110 previously characterized chemotherapy-naive women with primary breast cancer treated with anthracycline-containing chemotherapy served as a study group for mutational analysis by direct sequencing. Eight common SNPs in the 5-HT3 receptor genes, HTR3A, HTR3B, HTR3D and HTR3E, were selected for association analysis. Results: A nonsynonymous variant in HTR3D, p.G36A (rs6443930), was found to be over-represented in nonresponders, assuming a log-additive inheritance model (p = 0.048). Cox proportional regression analysis resulted in a hazards ratio of 0.36 for homozygous carriers of the C allele to vomit within 24 h after first chemotherapy administration (p = 0.049). Conclusion: Our data supports the hypothesis that 5-HT3 receptors play an important role in the pathogenesis of CINV. Along with previously identified HTR3 polymorphisms, the HTR3D p.G36A variant could also contribute to facilitating individual risk predictions.
DOI:doi:10.2217/pgs.10.67
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.2217/pgs.10.67
 Volltext: https://www.futuremedicine.com/doi/10.2217/pgs.10.67
 DOI: https://doi.org/10.2217/pgs.10.67
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:5-HT3
 breast cancer
 chemotherapy-induced nausea and vomiting
 CINV
 HTR3
 pharmacogenomics
 serotonin
 SNP
K10plus-PPN:1838155473
Verknüpfungen:→ Zeitschrift

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