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Status: Bibliographieeintrag

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Verfasst von:Kasper, Hans-Udo [VerfasserIn]   i
 Konze, Elisabeth [VerfasserIn]   i
 Dienes, Hans Peter [VerfasserIn]   i
 Stippel, Dirk Ludger [VerfasserIn]   i
 Schirmacher, Peter [VerfasserIn]   i
 Kern, Michael A. [VerfasserIn]   i
Titel:COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases
Verf.angabe:Hans-Udo Kasper, Elisabeth Konze, Hans Peter Dienes, Dirk Ludger Stippel, Peter Schirmacher and Michael Kern
E-Jahr:2010
Jahr:July 22, 2010
Umfang:7 S.
Fussnoten:Gesehen am 07.03.2023
Titel Quelle:Enthalten in: Anticancer research
Ort Quelle:Attiki, 2004
Jahr Quelle:2010
Band/Heft Quelle:30(2010), 6 vom: Juni, Seite 2017-2023
ISSN Quelle:1791-7530
Abstract:Nonsteroidal anti-inflammatory drugs are known to reduce the risk and mortality from colorectal carcinoma by inhibiting cyclo-oxygenases (COX). COX-2 expression was investigated immunohistologically in 57 patients with colorectal carcinomas and in the corresponding liver metastases using tissue microarray analysis. Ex vivo COX-2 inhibition with assessment of apoptosis was performed using precision-cut tissue slices of three human liver metastases. Following stimulation with different concentrations of the selective COX-2 inhibitor meloxicam, apoptosis was assessed immunohistochemically after 6 h and 12 h. All primary carcinomas and 56 out of the 57 liver metastases showed various degrees of cytoplasmatic COX-2 expression being with a reduction and in the liver metastases. There was a time- and concentration-dependent change in the number of apoptotic cells in tissue slices, however, this was without statistical significance. COX-2 is constantly involved in the carcinogenesis and metastatic process of colorectal cancer. The antineoplastic effect of COX-2 inhibition may be based on different pathways, including changes in sensitivity to apoptosis.
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kostenfrei: Volltext: https://ar.iiarjournals.org/content/30/6/2017
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adenoma
 Adult
 Aged
 Aged, 80 and over
 Colorectal Neoplasms
 Cyclooxygenase 2
 Cyclooxygenase 2 Inhibitors
 Dose-Response Relationship, Drug
 Female
 Humans
 Liver Neoplasms
 Male
 Meloxicam
 Middle Aged
 Thiazines
 Thiazoles
 Tissue Array Analysis
K10plus-PPN:1838425314
Verknüpfungen:→ Zeitschrift

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