Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Kasper, Hans-Udo [VerfasserIn]  |
| Konze, Elisabeth [VerfasserIn]  |
| Dienes, Hans Peter [VerfasserIn]  |
| Stippel, Dirk Ludger [VerfasserIn]  |
| Schirmacher, Peter [VerfasserIn]  |
| Kern, Michael A. [VerfasserIn]  |
Titel: | COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases |
Verf.angabe: | Hans-Udo Kasper, Elisabeth Konze, Hans Peter Dienes, Dirk Ludger Stippel, Peter Schirmacher and Michael Kern |
E-Jahr: | 2010 |
Jahr: | July 22, 2010 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 07.03.2023 |
Titel Quelle: | Enthalten in: Anticancer research |
Ort Quelle: | Attiki, 2004 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 30(2010), 6 vom: Juni, Seite 2017-2023 |
ISSN Quelle: | 1791-7530 |
Abstract: | Nonsteroidal anti-inflammatory drugs are known to reduce the risk and mortality from colorectal carcinoma by inhibiting cyclo-oxygenases (COX). COX-2 expression was investigated immunohistologically in 57 patients with colorectal carcinomas and in the corresponding liver metastases using tissue microarray analysis. Ex vivo COX-2 inhibition with assessment of apoptosis was performed using precision-cut tissue slices of three human liver metastases. Following stimulation with different concentrations of the selective COX-2 inhibitor meloxicam, apoptosis was assessed immunohistochemically after 6 h and 12 h. All primary carcinomas and 56 out of the 57 liver metastases showed various degrees of cytoplasmatic COX-2 expression being with a reduction and in the liver metastases. There was a time- and concentration-dependent change in the number of apoptotic cells in tissue slices, however, this was without statistical significance. COX-2 is constantly involved in the carcinogenesis and metastatic process of colorectal cancer. The antineoplastic effect of COX-2 inhibition may be based on different pathways, including changes in sensitivity to apoptosis. |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://ar.iiarjournals.org/content/30/6/2017 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Adenoma |
| Adult |
| Aged |
| Aged, 80 and over |
| Colorectal Neoplasms |
| Cyclooxygenase 2 |
| Cyclooxygenase 2 Inhibitors |
| Dose-Response Relationship, Drug |
| Female |
| Humans |
| Liver Neoplasms |
| Male |
| Meloxicam |
| Middle Aged |
| Thiazines |
| Thiazoles |
| Tissue Array Analysis |
K10plus-PPN: | 1838425314 |
Verknüpfungen: | → Zeitschrift |
COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases / Kasper, Hans-Udo [VerfasserIn]; July 22, 2010 (Online-Ressource)
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