COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases

• Verfasst von: Kasper, Hans-Udo [VerfasserIn]
• Verfasst von: Konze, Elisabeth [VerfasserIn]
• Verfasst von: Dienes, Hans Peter [VerfasserIn]
• Verfasst von: Stippel, Dirk Ludger [VerfasserIn]
• Verfasst von: Schirmacher, Peter [VerfasserIn]
• Verfasst von: Kern, Michael A. [VerfasserIn]
• Titel: COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases
• Verf.angabe: Hans-Udo Kasper, Elisabeth Konze, Hans Peter Dienes, Dirk Ludger Stippel, Peter Schirmacher and Michael Kern
• E-Jahr: 2010
• Jahr: July 22, 2010
• Umfang: 7 S.
• Fussnoten: Gesehen am 07.03.2023
• Titel Quelle: Enthalten in: Anticancer research
• Ort Quelle: Attiki, 2004
• Jahr Quelle: 2010
• Band/Heft Quelle: 30(2010), 6 vom: Juni, Seite 2017-2023
• ISSN Quelle: 1791-7530
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adenoma
• Sach-SW: Adult
• Sach-SW: Aged
• Sach-SW: Aged, 80 and over
• Sach-SW: Colorectal Neoplasms
• Sach-SW: Cyclooxygenase 2
• Sach-SW: Cyclooxygenase 2 Inhibitors
• Sach-SW: Dose-Response Relationship, Drug
• Sach-SW: Female
• Sach-SW: Humans
• Sach-SW: Liver Neoplasms
• Sach-SW: Male
• Sach-SW: Meloxicam
• Sach-SW: Middle Aged
• Sach-SW: Thiazines
• Sach-SW: Thiazoles
• Sach-SW: Tissue Array Analysis
• K10plus-PPN: 1838425314

Abstract

Nonsteroidal anti-inflammatory drugs are known to reduce the risk and mortality from colorectal carcinoma by inhibiting cyclo-oxygenases (COX). COX-2 expression was investigated immunohistologically in 57 patients with colorectal carcinomas and in the corresponding liver metastases using tissue microarray analysis. Ex vivo COX-2 inhibition with assessment of apoptosis was performed using precision-cut tissue slices of three human liver metastases. Following stimulation with different concentrations of the selective COX-2 inhibitor meloxicam, apoptosis was assessed immunohistochemically after 6 h and 12 h. All primary carcinomas and 56 out of the 57 liver metastases showed various degrees of cytoplasmatic COX-2 expression being with a reduction and in the liver metastases. There was a time- and concentration-dependent change in the number of apoptotic cells in tissue slices, however, this was without statistical significance. COX-2 is constantly involved in the carcinogenesis and metastatic process of colorectal cancer. The antineoplastic effect of COX-2 inhibition may be based on different pathways, including changes in sensitivity to apoptosis.