Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Kaya, Ziya [VerfasserIn]  |
| Katus, Hugo [VerfasserIn]  |
| Rose, Noel R. [VerfasserIn]  |
Titel: | Cardiac troponins and autoimmunity |
Titelzusatz: | their role in the pathogenesis of myocarditis and of heart failure |
Verf.angabe: | Ziya Kaya, Hugo A. Katus, Noel R. Rose |
Jahr: | 2010 |
Umfang: | 9 S. |
Fussnoten: | Online veröffentlicht am 14. Mai 2009 ; Gesehen am 08.03.2023 |
Titel Quelle: | Enthalten in: Clinical immunology |
Ort Quelle: | San Diego, Calif. : Elsevier, 1999 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 134(2010), 1, Seite 80-88 |
ISSN Quelle: | 1521-7035 |
Abstract: | Despite the widespread use of cardiac troponins as biomarkers for the diagnosis and quantitation of cardiac injury, the effect of troponin release and a possible autoimmune response to the troponins is unknown. Other investigators reported that programmed cell death-1 (PD-1)-receptor deficient mice developed severe cardiomyopathy with autoantibodies to troponin I. We found that immunization of genetically susceptible mice with troponin I but not troponin T induced a robust autoimmune response leading to marked inflammation and fibrosis in the myocardium. At later times, antibodies to cardiac myosin were detected in troponin-immunized mice. The severity of inflammation correlated with expression of chemokines RANTES, MIP-2, IP-10 and MCP-1 in the myocardium. Prior immunization with troponin I increased the severity of experimental infarctions, indicating that an autoimmune response to troponin I aggravates acute cardiac damage. Cardiac inflammation, fibrosis and functional impairment were transferred from immunized to naive recipients by CD4+ T cells, and the cytokine profile suggested both Th2 and Th17 profiles in A/J mice. Finally we identified an 18-mer of troponin I containing an immuno-dominant epitope. |
DOI: | doi:10.1016/j.clim.2009.04.008 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.clim.2009.04.008 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S152166160900638X |
| DOI: https://doi.org/10.1016/j.clim.2009.04.008 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Biomarkers |
| Cardiac troponins |
| Cardiomyopathy |
| Cytokine |
| Fibrosis |
| Immuno-dominant epitope |
| Inflammation |
| Myocardium |
| Myosin |
K10plus-PPN: | 1838555366 |
Verknüpfungen: | → Zeitschrift |
Cardiac troponins and autoimmunity / Kaya, Ziya [VerfasserIn]; 2010 (Online-Ressource)
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