Status: Bibliographieeintrag
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| Verfasst von: | Kuntz, Eva [VerfasserIn]  |
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| | Yusenko, Maria [VerfasserIn] |
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| | Nagy, Anetta [VerfasserIn] |
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| | Kovacs, Gyula [VerfasserIn] |
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| Titel: | Oligoarray comparative genomic hybridization of renal cell tumors that developed in patients with acquired cystic renal disease |
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| Verf.angabe: | Eva Kuntz, Maria V. Yusenko, Anetta Nagy, Gyula Kovacs |
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| E-Jahr: | 2010 |
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| Jahr: | 20 June 2010 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 08.03.2023 |
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| Titel Quelle: | Enthalten in: Human pathology |
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| Ort Quelle: | New York, NY [u.a.] : Elsevier, 1970 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 41(2010), 9 vom: Juni, Seite 1345-1349 |
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| ISSN Quelle: | 1532-8392 |
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| Abstract: | Renal cell carcinoma occurs at higher frequency in acquired cystic renal disease than in the general population. We have analyzed 4 tumors obtained from the kidneys of 2 patients with acquired cystic renal disease, including 2 conventional renal cell carcinomas and 2 acquired cystic renal disease-associated tumors, for genetic alterations. DNA changes were established by applying the 44K Agilent Oligonucleotide Array-Based CGH (Agilent Technologies, Waldbronn, Germany), and mutation of VHL gene was detected by direct sequencing of the tumor genome. DNA losses and mutation of the VHL gene, which are characteristic for conventional renal cell carcinomas, were seen in 2 of the tumors. The acquired cystic renal disease-associated eosinophilic-vacuolated cell tumor showed gain of chromosomes 3 and 16. No DNA alterations occurred in the papillary clear cell tumor. We suggest that not only the morphology but also the genetics of renal cell tumors associated with acquired cystic renal disease may differ from those occurring in the general population. |
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| DOI: | doi:10.1016/j.humpath.2009.09.022 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.humpath.2009.09.022 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0046817710000511 |
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| | DOI: https://doi.org/10.1016/j.humpath.2009.09.022 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Acquired cystic renal disease |
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| | Oligoarray CGH |
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| | Renal cell carcinoma |
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| | VHL mutation |
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| K10plus-PPN: | 1838580115 |
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| Verknüpfungen: | → Zeitschrift |
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Oligoarray comparative genomic hybridization of renal cell tumors that developed in patients with acquired cystic renal disease / Kuntz, Eva [VerfasserIn]; 20 June 2010 (Online-Ressource)
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