Predictors of treatment non-response for depression in a sample of female adolescents with risk-taking and self-injurious behavior

• Verfasst von: Vöckel, Jasper [VerfasserIn]
• Verfasst von: Sigrist, Christine [VerfasserIn]
• Verfasst von: Kaess, Michael [VerfasserIn]
• Verfasst von: Koenig, Julian [VerfasserIn]
• Titel: Predictors of treatment non-response for depression in a sample of female adolescents with risk-taking and self-injurious behavior
• Titelzusatz: a one year follow-up
• Verf.angabe: Jasper Vöckel, Christine Sigrist, Michael Kaess, Julian Koenig
• Jahr: 2023
• Umfang: 7 S.
• Fussnoten: Online verfügbar: 29. Dezember 2022 ; Gesehen am 09.03.2023
• Titel Quelle: Enthalten in: Journal of affective disorders
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1979
• Jahr Quelle: 2023
• Band/Heft Quelle: 324(2023), Seite 129-135
• ISSN Quelle: 1573-2517
• DOI: doi:10.1016/j.jad.2022.12.073
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adolescents
• Sach-SW: Depression
• Sach-SW: Predictors
• Sach-SW: Treatment response
• K10plus-PPN: 1838716580

Abstract

Objective - Depressive disorders (DD) are highly prevalent among adolescents. While up to 60 % do not respond to treatment, evidence on predictors of treatment non-response in this age group is mixed, impeding meaningful clinical implications. Drawing on a consecutive clinical cohort of adolescents with risk taking and self-injurious behavior, the present study aimed to identify predictors of treatment non-response for female DD in a naturalistic one year follow-up. - Methods - The sample comprised female adolescents with verified DD (n = 152). Patients underwent assessments at baseline (T0) and follow-up (T1). Sociodemographic factors (e.g., age), clinical measures (e.g., symptom severity, trauma), and treatment variables (e.g. number of psychotherapy sessions), were analyzed as potential predictors of treatment non-response in unadjusted analyses and analyses adjusting for treatment intensity and age at baseline. Treatment response was defined based on not fulfilling formal diagnosis for DD at follow-up (52.3 %; n = 80) or the 50 % decrease in self-reported depressive symptoms (21.1 %; n = 32) from T0 to T1. - Results - Greater depressive and overall symptom severity, greater frequency of self-injuries, history of suicide attempts and history of childhood trauma at T0 were robustly associated with treatment non-response based on diagnostic interviews. Only a lower number of siblings was robustly associated with treatment non-response based on self-reports. - Limitations - Findings may not generalize to other treatment settings. - Conclusion - Collectively, our results highlight overall symptom severity as significant predictor of treatment non-response in female adolescents with depression. Methodological differences (interviews versus self-reports) and potential implications from these findings for clinical practice are discussed.