Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues

• Verfasst von: Abad, Miriam [VerfasserIn]
• Verfasst von: Nardi, Martina [VerfasserIn]
• Verfasst von: Oriol, Luis [VerfasserIn]
• Verfasst von: Piñol, Milagros [VerfasserIn]
• Verfasst von: Blasco, Eva [VerfasserIn]
• Titel: Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues
• Verf.angabe: Miriam Abad, Martina Nardi, Luis Oriol, Milagros Piñol and Eva Blasco
• Jahr: 2023
• Umfang: 10 S.
• Fussnoten: Online veröffentlicht: 22. November 2022 ; Gesehen am 09.03.2023
• Titel Quelle: Enthalten in: Polymer chemistry
• Ort Quelle: Cambridge : RSC Publ., 2010
• Jahr Quelle: 2023
• Band/Heft Quelle: 14(2023), 1, Seite 71-80
• ISSN Quelle: 1759-9962
• DOI: doi:10.1039/D2PY01250B
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Forschungsdaten: Abad, Miriam: Aqueous seeded RAFT polymerization for the preparation of self-assemblies containing nucleobase analogues [data]
• K10plus-PPN: 1838724567

Abstract

Self-assemblies containing the nucleobase analogue 2,6-diacylaminopyridine (DAP) have been successfully prepared for the first time by aqueous seeded RAFT polymerization in high concentrations. For this purpose, a diblock copolymer containing poly(ethylene glycol) (PEG) and DAP polymethacrylate blocks was used as a macro-chain-transfer agent (PEG124-b-PDAP9-CTA) for the polymerization of 2-hydroxypropyl methacrylate (HPMA) in water. From the systematic variation of the degree of polymerization and solid concentration, a phase diagram has been generated that correlates both variables with the morphologies of this new system. Self-assemblies have been characterized by TEM and DLS, observing morphologies from low to high order (from spherical micelles to worms and to vesicles). Self-assembly morphologies are stable for almost a year, except in the case of worms that turn into spherical micelles after a few weeks. In addition, H-bonding supramolecular functionalization of the DAP repeating units during aqueous seeded RAFT polymerization has been examined by functionalization with a cross-linker with four thymine groups. Finally, the loading and the subsequent release of Nile Red have been proven in both supramolecular cross-linked and non-cross-linked self-assemblies.